Primary hyperepinephrinemia in patients without pheochromocytoma.

Abstract

Clinical features of epinephrine release led to the finding of spontaneously elevated plasma epinephrine concentrations in five patients, in four of whom plasma norepinephrine concentrations were normal. Adrenal medullary hyperplasia was suspected in one patient, whose first cousin had multiple endocrine neoplasia type IIa, and in two others, all of whom have experienced relief from symptoms during propranolol or atenolol administration. The other two patients had unilateral adrenal cysts, with negative metaiodobenzylguanidine scans and no histological evidence of pheochromocytoma, but complete relief of symptoms by excision of the cysts. In one patient, Cushing's syndrome and associated hypertension, diabetes, and ischemic finger-tip ulceration all disappeared after surgery. It is concluded that spontaneous hyperepinephrinemic manifestations can be received by beta-blockers or, when an adrenal mass is present, by unilateral adrenalectomy even when the metalodobenzylguanidine test result is negative.

• Authors: D H Streeten, G H Anderson Jr, M Lebowitz, P J Speller
• Journal: Archives of internal medicine (Arch Intern Med) Vol. 150 Issue 7 Pg. 1528-33 (Jul 1990) ISSN: 0003-9926 [Print] United States
• PMID: 2369252 (Publication Type: Case Reports, Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Epinephrine

Topics

• Adrenal Gland Diseases (blood, diagnosis, therapy)
• Adrenal Gland Neoplasms (diagnosis)
• Aged
• Cysts (blood, diagnosis, surgery)
• Diagnosis, Differential
• Epinephrine (blood)
• Female
• Humans
• Hyperplasia
• Middle Aged
• Pheochromocytoma (diagnosis)