Inhibition of mortalin expression reverses cisplatin resistance and attenuates growth of ovarian cancer cells.

Abstract

The heat shock protein mortalin is frequently overexpressed in human malignancies. In this study, an assessment of mortalin expression using ovarian cancer tissue microarrays suggested that mortalin overexpression might be related to drug resistance. Using a short hairpin (sh) RNA approach, we evaluated the effect of reducing mortalin expression in vitro and in vivo. The results of our study show that elevated levels of mortalin expression increase cancer cell resistance to cisplatin-induced cytotoxicity and identify mortalin as a potential therapeutic target for improved treatment of drug-resistant ovarian cancer.

• Authors: Ling Yang, Hongyan Li, Yizhou Jiang, Ji Zuo, Wen Liu
• Journal: Cancer letters (Cancer Lett) Vol. 336 Issue 1 Pg. 213-21 (Aug 09 2013) ISSN: 1872-7980 [Electronic] Ireland
• PMID: 23665506 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

Chemical References

• HSP70 Heat-Shock Proteins
• mortalin
• Cisplatin

Topics

• Active Transport, Cell Nucleus
• Animals
• Apoptosis
• Cell Line, Tumor
• Cell Nucleus (metabolism)
• Cell Proliferation
• Cisplatin (pharmacology)
• Drug Resistance, Neoplasm
• Female
• HSP70 Heat-Shock Proteins (antagonists & inhibitors, metabolism)
• Humans
• Mice
• Mice, Inbred BALB C
• Mice, Nude
• Middle Aged
• Neoplasm Invasiveness
• Neoplasm Transplantation
• Ovarian Neoplasms (metabolism)