Meta-analysis of MMP2, MMP3, and MMP9 promoter polymorphisms and head and neck cancer risk.

Abstract

BACKGROUND:

The 1306 C>T, 1171 5A>6A, and 1562C>T polymorphisms of matrix metalloproteinase (MMP) 2, MMP3, and MMP9 genes, respectively, have been found to be functional and may contribute to head and neck carcinogenesis. However, the results of case-control studies examining associations between MMP polymorphisms and head and neck cancer (HNC) risk remain inconclusive. Therefore, we performed a meta-analysis to further evaluate the role of these polymorphisms in HNC development.

METHODS:

We searched PubMed, ISI Web of Knowledge, MEDLINE, Embase, and Google Scholar to identify all published case-control studies of MMP2-1306 C>T, MMP3-1171 5A>6A, and MMP9-1562 C>T polymorphisms and HNC risk in the meta-analysis. Odds ratios (ORs) and 95% confidence intervals (CIs) were used to assess the association between these polymorphisms and HNC risk.

RESULTS:

Thirteen studies were included in this meta-analysis. For MMP2-1306 C>T polymorphism, significant associations were observed under three genetic models both in overall comparison and in a hospital-based subgroup, and in oral cavity cancer and nasopharyngeal cancer under dominant model as well. For MMP3-1171 5A>6A and MMP9-1562 C>T polymorphisms, no association was found in overall comparison; however, in subgroup analyses based on ethnicity and tumor site, significant associations were detected between the MMP3-1171 5A>6A polymorphism and HNC risk in a European population and pharyngeal/laryngeal cancer under two genetic contrasts.

CONCLUSION:

This meta-analysis suggests that the MMP2-1306 C>T polymorphism is associated with HNC risk, as is the MMP3-1171 5A>6A polymorphism specifically in some subgroups. Further studies with larger sample sizes are warranted.

• Authors: Caiyun Zhang, Chao Li, Minhui Zhu, Qingzhou Zhang, Zhenghua Xie, Gang Niu, Xicheng Song, Lei Jin, Guojun Li, Hongliang Zheng
• Journal: PloS one (PLoS One) Vol. 8 Issue 4 Pg. e62023 ( 2013) ISSN: 1932-6203 [Electronic] United States
• PMID: 23637955 (Publication Type: Journal Article, Meta-Analysis, Research Support, Non-U.S. Gov't)

Chemical References

• Matrix Metalloproteinase 3
• Matrix Metalloproteinase 2
• Matrix Metalloproteinase 9

Topics

• Alleles
• Case-Control Studies
• Genetic Predisposition to Disease
• Genotype
• Head and Neck Neoplasms (genetics)
• Humans
• Matrix Metalloproteinase 2 (genetics)
• Matrix Metalloproteinase 3 (genetics)
• Matrix Metalloproteinase 9 (genetics)
• Odds Ratio
• Polymorphism, Single Nucleotide
• Promoter Regions, Genetic
• Publication Bias
• Risk