Vitamin D deficiency and hypocalcemia in an infant with newly diagnosed AML.

Abstract

We report a 4-month-old male presenting with hypocalcemia, hyperleukocytosis, and newly diagnosed acute myeloid leukemia. He received chemical leukoreduction through low-dosed cytarabine, with appropriate decrease in his white blood cell count and development of subsequent symptomatic hypocalcemia, which did not normalize until the underlying vitamin D deficiency was addressed. A single dose of cholecalciferol raised the serum calcium concentration to an appropriate level within 48 hours. For infants with newly diagnosed leukemia and prolonged hypocalcemia, vitamin D deficiency should be considered in the differential diagnosis and managed appropriately.

• Authors: Cathleen Cook, Valeria Bernardo, John Shelso, Raul C Ribeiro
• Journal: Journal of pediatric hematology/oncology (J Pediatr Hematol Oncol) Vol. 36 Issue 2 Pg. e118-20 (Mar 2014) ISSN: 1536-3678 [Electronic] United States
• PMID: 23619111 (Publication Type: Case Reports, Journal Article)

Topics

• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Humans
• Hypocalcemia (complications, physiopathology)
• Infant
• Leukemia, Myeloid, Acute (complications, drug therapy, physiopathology)
• Male
• Vitamin D Deficiency (complications, physiopathology)