Current therapy of hypertension. A pharmacologic approach.

Abstract	Adequate treatment of hypertension requires that the physician understand the pharmacologic actions of antihypertensive agents. Although no drug is without adverse reactions, it should be possible to choose an agent or combination of agents which can effectively lower blood pressure and be tolerated by the patient. The indications, proposed mechanisms of actions and adverse effects of the following antihypertensive drugs are discussed: thiazide diuretics, spironolactone, triamterene, trimethaphan, Rauwolfia alkaloids. guanethidine, bethanidine, methyldopa, clonidine, pargyline, propranolol, hydrazaline, minoxidil, guancydine, diazoxide and sodium nitroprusside.
Authors	L I Goldberg
Journal	The American journal of medicine (Am J Med) Vol. 58 Issue 4 Pg. 489-94 (Apr 1975) ISSN: 0002-9343 [Print] United States
PMID	235841 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
Chemical References	Adrenergic alpha-Antagonists Adrenergic beta-Antagonists Antihypertensive Agents Benzothiadiazines Diuretics Ganglionic Blockers Monoamine Oxidase Inhibitors Secologanin Tryptamine Alkaloids Sodium Chloride Symporter Inhibitors Vasodilator Agents Spironolactone Methyldopa Reserpine Triamterene Norepinephrine Guanethidine
Topics	Adrenergic alpha-Antagonists (therapeutic use) Adrenergic beta-Antagonists (therapeutic use) Antihypertensive Agents (classification, therapeutic use) Benzothiadiazines Diuretics Dose-Response Relationship, Drug Drug Therapy, Combination Ganglionic Blockers (therapeutic use) Guanethidine (adverse effects, pharmacology, therapeutic use) Humans Hypertension (drug therapy) Methyldopa (therapeutic use) Monoamine Oxidase Inhibitors (therapeutic use) Norepinephrine (biosynthesis) Reserpine (therapeutic use) Secologanin Tryptamine Alkaloids (therapeutic use) Sodium Chloride Symporter Inhibitors (therapeutic use) Spironolactone (therapeutic use) Sympathetic Nervous System Synaptic Transmission Triamterene (therapeutic use) Vasodilator Agents (therapeutic use)

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