Abstract | OBJECTIVE: METHODS: A cross-sectional study was performed of 30 patients with molecular diagnosis of sickle cell anemia. Patients were stratified into two groups, according to the presence of iron overload: Iron overload (n = 15) and Non- iron overload (n = 15). Biochemical analyses were performed utilizing the Wiener CM 200 automatic analyzer. The interleukin-10 level was measured by capture ELISA using the BD OptEIAT commercial kit. Oxidative stress parameters were determined by spectrophotometry. Statistical analysis was performed using GraphPad Prism software (version 5.0) and statistical significance was established for p-values < 0.05 in all analyses. RESULTS: CONCLUSION: The results of this study are important to develop further consistent studies that evaluate the effect of iron overload on the inflammatory profile and oxidative stress of patients with sickle cell anemia.
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Authors | Maritza Cavalcante Barbosa, Talyta Ellen Jesus Dos Santos, Geane Félix de Souza, Lívia Coêlho de Assis, Max Victor Carioca Freitas, Romélia Pinheiro Gonçalves |
Journal | Revista brasileira de hematologia e hemoterapia
(Rev Bras Hematol Hemoter)
Vol. 35
Issue 1
Pg. 29-34
( 2013)
ISSN: 1516-8484 [Print] Brazil |
PMID | 23580881
(Publication Type: Journal Article)
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