Mesenteric paraganglioma: Report of a case.

Abstract

We report a rare case of paraganglioma that developed in the mesentery of terminal ileum. A 78-year-old woman complained of right-sided abdominal pain. Abdominal computed tomography revealed a solid heterogeneously enhanced mass in the right lower abdomen. The tumor was laparoscopically excised. The mesenteric tumor was well circumscribed, ovoid, and encapsulated and measured 3 cm × 1.5 cm × 1.5 cm. Histological examination showed a cellular neoplasm comprised of nests and groups of tumor cells separated by fibrovascular connective tissue, giving a characteristic nested Zellballen pattern. Immunohistochemically, the tumor cells were positive for chromogranin, synaptophysin, CD56, and vimentin and negative for cytokeratins, SMA, CD34, CD117/c-kit and S100. On the basis of histologic and immunohistochemical features, a diagnosis of mesenteric paraganglioma was made. The operative and postoperative courses were unremarkable, and the patient was discharged on postoperative day 7. She was doing well 1 year after the surgery with no signs of recurrence. Extra-adrenal paragangliomas most commonly develop adjacent to the aorta, particularly the area corresponding to the organ of Zuckerkandl. Mesenteric paraganglioma, as in our case, is extremely rare; only 11 cases have been reported in the literature. We herein discuss the clinical findings of these cases.

• Authors: Takeshi Fujita, Kinji Kamiya, Yoshiaki Takahashi, Shinichiro Miyazaki, Ichirota Iino, Hirotoshi Kikuchi, Yoshihiro Hiramatsu, Manabu Ohta, Satoshi Baba, Hiroyuki Konno
• Journal: World journal of gastrointestinal surgery (World J Gastrointest Surg) Vol. 5 Issue 3 Pg. 62-7 (Mar 27 2013) ISSN: 1948-9366 [Print] United States
• PMID: 23556063 (Publication Type: Journal Article)