Abstract | BACKGROUND: There have been increasing reports of methicillin-resistant Staphylococcus aureus (MRSA) infections in the community, but it is unclear whether infectious organisms in open fracture infections have changed and if our current regimen of antibiotic prophylaxis is therefore obsolete. QUESTIONS/PURPOSES: METHODS: We performed a retrospective cohort study on 189 patients with 202 open fractures treated from 2009 to 2010. During the followup, patients were evaluated for signs of infection using the Centers for Disease Control and Prevention criteria. We determined the organisms using routine microbiology culture. The minimum followup was 3 months (median, 47 months; range, 3-108 months). RESULTS: Of the 202 open fractures, 20 (10%) developed infections. The most common organism was Staphylococcus, whereas five (25%) of those infected were positive for MRSA, and 11 (55%) of those with infection were cultured for at least one Gram-negative organism. Six (30%) open fractures had infections that grew out multiple organisms. The incidence of MRSA infections in our open fracture population was 2.5%. CONCLUSIONS: LEVEL OF EVIDENCE: Level IV, retrospective case-series. See the Guidelines for Authors for a complete description of levels of evidence.
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Authors | Antonia F Chen, Verena M Schreiber, Wesley Washington, Nalini Rao, Andrew R Evans |
Journal | Clinical orthopaedics and related research
(Clin Orthop Relat Res)
Vol. 471
Issue 10
Pg. 3135-40
(Oct 2013)
ISSN: 1528-1132 [Electronic] United States |
PMID | 23543416
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Adult
- Aged
- Anti-Bacterial Agents
(therapeutic use)
- Female
- Fractures, Open
(drug therapy, microbiology)
- Gram-Negative Bacterial Infections
(drug therapy, epidemiology, microbiology)
- Humans
- Incidence
- Male
- Methicillin-Resistant Staphylococcus aureus
(isolation & purification)
- Middle Aged
- Retrospective Studies
- Staphylococcal Infections
(drug therapy, epidemiology, microbiology)
- United States
(epidemiology)
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