Abstract | PURPOSE: MATERIALS AND METHODS: All patients or their relatives signed informed consent. By using high-performance liquid chromatography, plasma glutamate concentrations were determined in 74 patients treated with CAS. Blood samples were obtained with arterial and peripheral venous catheterization before and after the procedure, and venous blood samples were obtained 24, 48, and 72 hours after CAS. Glutamate concentrations were also analyzed in two different control groups: 16 patients without carotid stenosis before and after diagnostic cerebral angiography and 20 patients treated with coronary angioplasty and stent placement. The χ(2) test, t test, and analysis of variance were used to compare glutamate concentrations among the groups. RESULTS: Baseline glutamate concentrations were similar between patients who underwent CAS and both control groups. In CAS patients, glutamate concentrations in venous blood increased immediately after the procedure (354.1 μmol/L ± 132.8) and returned to baseline levels at 24 hours (129.5 μmol/L ± 56.8) (P < .0001). Glutamate concentrations remained unchanged over time in both control groups. CONCLUSION: A rapid increase in plasma glutamate levels occurs after CAS procedures, unrelated to stroke.
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Authors | Florentino Nombela, Miguel Blanco, Natalia Pérez de la Ossa, José Luis Caniego, Tomás Sobrino, Domingo Escudero, Francisco Campos, María Ángeles Moro, Ignacio Lizasoaín, Antoni Dávalos, José Castillo, José Vivancos |
Journal | Radiology
(Radiology)
Vol. 268
Issue 2
Pg. 515-20
(Aug 2013)
ISSN: 1527-1315 [Electronic] United States |
PMID | 23525205
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Aged
- Aged, 80 and over
- Analysis of Variance
- Angioplasty
- Biomarkers
(blood)
- Brain Ischemia
(blood, diagnostic imaging)
- Carotid Stenosis
(diagnostic imaging, surgery)
- Case-Control Studies
- Cerebral Angiography
- Chi-Square Distribution
- Chromatography, High Pressure Liquid
- Female
- Glutamic Acid
(blood)
- Humans
- Male
- Middle Aged
- Prospective Studies
- Statistics, Nonparametric
- Stents
- Ultrasonography, Doppler, Transcranial
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