Clindamycin phosphate 1.2%-benzoyl peroxide (5% or 2.5%) plus tazarotene cream 0.1% for the treatment of acne.

Abstract

Acne is a multifactorial chronic dermatosis that can be effectively treated with adjuvant medications. The objective of our study was to compare the tolerability and efficacy of 2 adjuvant therapies combining clindamycin phosphate 1.2%-benzoyl peroxide 5% (CLNP-BPO5) or clindamycin phosphate 1.2%-benzoyl peroxide 2.5% (CLNP-BPO2.5) fixed-dose gels with tazarotene (TZ) cream 0.1% (CLNP-BPO5/TZ vs CLNP-BPO2.5/TZ) when applied topically once daily for 12 weeks in participants with moderate to severe facial acne. Forty participants were randomized to receive CLNP-BPO5/TZ or CLNP-BPO2.5/TZ in a parallel-group study and were evaluated at baseline as well as weeks 1, 2, 4, 8, and 12 (or at early termination). In both groups, tolerability assessments increased by week 1 but gradually returned toward baseline levels by week 12. At week 4, the mean change in burning/stinging was significantly higher in the CLNP-BPO5/TZ group compared with the CLNP-BPO2.5/TZ group (P<.05). No other significant differences were observed for the tolerability, efficacy, quality of life (QOL), or participant preference assessments. Our study shows that CLNP-BPO5 or CLNP-BPO2.5 fixed-dose gels in combination with TZ cream 0.1% are generally well-tolerated and effective treatments of moderate to severe facial acne when applied once daily for up to 12 weeks.

• Authors: Sunil S Dhawan, Jennifer Gwazdauskas
• Journal: Cutis (Cutis) Vol. 91 Issue 2 Pg. 99-104 (Feb 2013) ISSN: 0011-4162 [Print] United States
• PMID: 23513559 (Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Dermatologic Agents
• Drug Combinations
• Gels
• Nicotinic Acids
• Ointments
• clindamycin phosphate benzoyl peroxide combination
• Clindamycin
• tazarotene
• Benzoyl Peroxide

Topics

• Acne Vulgaris (drug therapy)
• Administration, Topical
• Adolescent
• Adult
• Benzoyl Peroxide (administration & dosage, therapeutic use)
• Chi-Square Distribution
• Child
• Clindamycin (administration & dosage, therapeutic use)
• Dermatologic Agents (administration & dosage, therapeutic use)
• Drug Combinations
• Face
• Female
• Gels
• Humans
• Male
• Nicotinic Acids (administration & dosage, therapeutic use)
• Ointments
• Quality of Life
• Severity of Illness Index
• Single-Blind Method
• Statistics, Nonparametric
• Surveys and Questionnaires
• Treatment Outcome