Abstract | BACKGROUND: METHODS: During our animal experiment from week 11 to 22 in each case seven ZDF rats received an antidiabetic treatment with either insulin (ZDF+I) or metformin (ZDF+M). Six normoglycemic ZL and six untreated ZDF rats served as controls. Blood glucose was measured at least weekly and serum adiponectin levels were quantified via ELISA in week 11 and 22. The direct vasodilatory response of their isolated mesenteric resistance arteries to adiponectin as well as the endothelium-dependent and -independent function was evaluated in a small vessel myograph. Additionally, the expression of different components of the adiponectin signaling pathway in the resistance arteries was quantified by real-time RT-PCR. RESULTS: CONCLUSIONS:
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Authors | Peter M Schmid, Markus Resch, Christian Schach, Christoph Birner, Guenter A Riegger, Andreas Luchner, Dierk H Endemann |
Journal | Cardiovascular diabetology
(Cardiovasc Diabetol)
Vol. 12
Pg. 46
(Mar 18 2013)
ISSN: 1475-2840 [Electronic] England |
PMID | 23497197
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Adaptor Proteins, Signal Transducing
- Adiponectin
- Appl1 protein, rat
- Biomarkers
- Hypoglycemic Agents
- Nerve Tissue Proteins
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Topics |
- Adaptor Proteins, Signal Transducing
(biosynthesis)
- Adiponectin
(blood)
- Animals
- Biomarkers
(blood, metabolism)
- Diabetes Mellitus, Type 2
(blood, drug therapy, metabolism)
- Endothelium, Vascular
(drug effects, metabolism, physiopathology)
- Gene Expression Regulation
- Hypoglycemic Agents
(pharmacology, therapeutic use)
- Male
- Mesenteric Arteries
(drug effects, metabolism)
- Nerve Tissue Proteins
(biosynthesis)
- Rats
- Rats, Zucker
- Treatment Outcome
- Vasodilation
(drug effects, physiology)
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