Abstract | BACKGROUND: MATERIAL AND METHODS: A population of 71 patients with NAFLD was recruited in a cross sectional study. A biochemical analysis of serum was measured. Genotype of G1359A polymorphism of CB1 receptor gene CB1 receptor was studied. Forty one patients (36.9%) had the genotype G1359G (wild type group) and twenty nine (26.1%) patients G1359A or A1359A (mutant type group). RESULTS: Twenty four 24 patients (32,3%) had a Brunt grade > 4 and 12 patients (17%) had a significative fibrosis (F > = 2). HOMA values were higher in wild type group than mutant type group. Adiponectin and visfatin levels were higher in mutant type group. Moreover, TNF-alpha and resistin levels were higher in wild type group than mutant type group. Patients with mutant genotype showed less frequently elevated levels of AST. AST > 40 UI/L was detected in 28.5% of patients in the mutant vs. 53% of patients with wild genotype, p < 0.05. Patients with mutant type group presented a percentage of Brunt grade > = 4 less frequently than patients with wild type group (28.5%vs 7.1%). CONCLUSION: A variant of the polymorphism G1359A CBR1 is associated with lower levels of HOMA, TNF-alpha, resistin and higher levels of adiponectin than patients with the wild variant of this polymorphism. Besides, patients with A allele variant shown lower Brunt grade in liver biopsy.
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Authors | R Aller, D A de Luis, D Pacheco, M C Velasco, R Conde, O Izaola, M González Sagrado |
Journal | Nutricion hospitalaria
(Nutr Hosp)
2012 Sep-Oct
Vol. 27
Issue 5
Pg. 1637-42
ISSN: 1699-5198 [Electronic] Spain |
PMID | 23478717
(Publication Type: Journal Article)
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Chemical References |
- Adipokines
- Blood Glucose
- Receptor, Cannabinoid, CB1
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Topics |
- Adipokines
(blood)
- Adult
- Anthropometry
- Biopsy
- Blood Glucose
(metabolism)
- Body Weight
(physiology)
- Fatty Liver
(blood, genetics, pathology)
- Female
- Genotype
- Humans
- Insulin Resistance
(genetics)
- Liver
(enzymology)
- Male
- Middle Aged
- Non-alcoholic Fatty Liver Disease
- Polymerase Chain Reaction
- Polymorphism, Genetic
- Receptor, Cannabinoid, CB1
(genetics)
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