Abstract |
Inflammatory cell infiltration in tumor stroma may represent the interaction between the tumor and the immune system. The significance of immunoglobulin (Ig) G4+ plasmacytic infiltration, however, is poorly understood. Here, we analyzed the number of stromal IgG4+ plasma cells and the IgG4/ IgG ratio of plasma cells in 294 primary non-small cell lung cancers (NSCLCs) using tissue microarray (TMA) and conventional surgical specimens. In TMA, 35 (12%) cases of NSCLC revealed more than 20 IgG4+ plasma cells per high-power field. In surgical specimens, most (97%) of those IgG4+ plasma cell-enriched cases showed obliterative phlebitis or arteritis, one of the key morphologic features of IgG4-related disease, within or at the periphery of the tumor. Clinically, none of the patients showed symptoms associated with IgG4-related systemic diseases. In patients with stage I squamous cell carcinoma, IgG4-enriched stroma was significantly associated with a favorable prognosis (P = .04). In conclusion, considerable IgG4+ plasma cell infiltration can be seen in a minority of cases of NSCLC and might contribute to prognostic modulation of NSCLC.
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Authors | Masakazu Fujimoto, Akihiko Yoshizawa, Shinji Sumiyoshi, Makoto Sonobe, Masashi Kobayashi, Itsuko Koyanagi, Wulamujiang Aini, Tatsuaki Tsuruyama, Hiroshi Date, Hironori Haga |
Journal | Human pathology
(Hum Pathol)
Vol. 44
Issue 8
Pg. 1569-76
(Aug 2013)
ISSN: 1532-8392 [Electronic] United States |
PMID | 23465276
(Publication Type: Journal Article)
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Copyright | Copyright © 2013 Elsevier Inc. All rights reserved. |
Chemical References |
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Carcinoma, Non-Small-Cell Lung
(immunology, pathology)
- Female
- Humans
- Immunoglobulin G
(immunology)
- Immunohistochemistry
- Kaplan-Meier Estimate
- Lung Neoplasms
(immunology, pathology)
- Male
- Middle Aged
- Plasma Cells
(immunology, pathology)
- Prognosis
- Stromal Cells
(immunology, pathology)
- Tissue Array Analysis
- Young Adult
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