Dietary intake of folate, B-vitamins and methionine and breast cancer risk among Hispanic and non-Hispanic white women.
Abstract | BACKGROUND: OBJECTIVE: To determine if dietary intakes of folate, B-vitamins (B2, B6, B12) and methionine are associated with breast cancer risk and ER status in Hispanic, and non-Hispanic White women in the southwestern U.S. MATERIALS AND METHODS: Primary breast cancer cases (n = 2,325) in the 4-Corners region (Arizona, Colorado, New Mexico and Utah), diagnosed between October 1999 and May 2004, were identified through state cancer registries. Controls (n = 2,525) were frequency-matched by ethnicity and age (±5 years). Dietary intake, physical activity and other exposures were assessed using in-person interviews. Risk was assessed through multivariable and multinomial logistic regression with adjustment for relevant covariates. RESULT: While there was no overall association with breast cancer, the highest quartile of folate intake was marginally inversely associated with ER- breast cancer (Odds Ratio (OR) = 0.50, 95% CI 0.25-1.00, p for trend = 0.07). Vitamin B12 intake was inversely associated with breast cancer also (OR = 0.73, 95% CI 0.53-1.00, p for trend = 0.06), particularly for the highest quartile of ER+ breast cancer (OR = 0.67, 95% CI 0.46-0.99, p for trend = 0.06), among NHW women (OR = 0.49, 95% CI 0.29-0.81, p for trend = 0.01) and invasive breast cancer (OR = 0.63; 95% CI: 0.42, 0.93, P(trend) = 0.01). Methionine intake was also inversely associated with ER+ breast cancer (OR for 4th quartile = 0.83, 95% CI 0.66-1.03, p for trend = 0.04), primarily among Hispanic women (OR = 0.71, 95% CI 0.47-1.06, and P for trend = 0.02). CONCLUSION:
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Authors | Dongyan Yang, Richard N Baumgartner, Martha L Slattery, Chenxi Wang, Anna R Giuliano, Maureen A Murtaugh, Betsy C Risendal, Tim Byers, Kathy B Baumgartner |
Journal | PloS one
(PLoS One)
Vol. 8
Issue 2
Pg. e54495
( 2013)
ISSN: 1932-6203 [Electronic] United States |
PMID | 23408942
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Chemical References |
- Vitamin B Complex
- Folic Acid
- Methionine
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Topics |
- Breast Neoplasms
(epidemiology, ethnology)
- Female
- Folic Acid
(administration & dosage)
- Hispanic or Latino
- Humans
- Methionine
(administration & dosage)
- Risk Factors
- Vitamin B Complex
(administration & dosage)
- White People
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