Abstract | BACKGROUND: METHODS: This study included men who were diagnosed with invasive breast cancer between 2005 and 2009 with known estrogen receptor (ER) and progesterone receptor (PR) (together, hormone receptor [HR]) status and HER2 status reported to the California Cancer Registry. Among the men with HR-positive tumors, survival probabilities between groups were compared using log-rank tests. RESULTS: Six hundred six patients were included. The median age at diagnosis was 68 years. Four hundred ninety-four men (81.5%) had HR-positive tumors (defined as ER-positive and/or PR-positive and HER2-negative). Ninety men (14.9%) had HER2-positive tumors, and 22 (3.6%) had triple receptor-negative (TN) tumors. Among the patients with HR-positive tumors, non-Hispanic black men and Hispanic men were more likely to have PR-negative tumors than non-Hispanic white men. No statistically significant differences in survival were observed according to tumor subtype (P = .08). Differences in survival according to race/ethnicity were observed among all patients (P = .087) and among those with HR-positive tumors (P = .0170), and non-Hispanic black men had poorer outcomes. CONCLUSIONS: In this large, representative cohort of men with breast cancer, the distribution of tumor subtypes was different from that reported for women and varied by patient race/ethnicity. Non-Hispanic black men were more likely to have TN tumors and ER-positive/PR-negative tumors than white men.
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Authors | Mariana Chavez-Macgregor, Christina A Clarke, Daphne Lichtensztajn, Gabriel N Hortobagyi, Sharon H Giordano |
Journal | Cancer
(Cancer)
Vol. 119
Issue 9
Pg. 1611-7
(May 01 2013)
ISSN: 1097-0142 [Electronic] United States |
PMID | 23341341
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.)
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Copyright | Copyright © 2013 American Cancer Society. |
Chemical References |
- Receptors, Estrogen
- Receptors, Progesterone
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Topics |
- Aged
- Breast Neoplasms, Male
(classification, epidemiology, ethnology, metabolism)
- California
(epidemiology)
- Genes, erbB-2
- Humans
- Male
- Population Surveillance
- Racial Groups
- Receptors, Estrogen
(metabolism)
- Receptors, Progesterone
(metabolism)
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