Male Breast Neoplasms (Male Breast Cancer)

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210 relevant articles (7 outcomes, 17 trials/studies) found for this Disease

Description: Any neoplasms of the male breast. These occur infrequently in males in developed countries, the incidence being about 1% of that in females.

Also Known As:

Male Breast Cancer; Breast Neoplasms, Male; Breast Cancer, Male; Breast Carcinoma, Male; Breast Tumors, Male; Neoplasms, Male Breast; Tumors, Breast, Male; Breast Neoplasm, Male; Breast Tumor, Male; Cancer, Male Breast; Carcinoma, Male Breast; Male Breast Carcinoma; Male Breast Neoplasm; Male Breast Tumor; Male Breast Tumors; Neoplasm, Male Breast; Tumor, Male Breast; Tumors, Male Breast; Neoplasms, Breast, Male

Relationship Network

Disease Context: Research Results

Neoplasms: 415397

Neoplasms by Site: 1

Breast Neoplasms: 65247

Male Breast Neoplasms: 210

Skin and Connective Tissue Diseases

Skin Diseases: 6187

Breast Diseases: 954

Breast Neoplasms: 65247

Male Breast Neoplasms: 210

Related Diseases

1.	Neoplasm Metastasis (Metastasis)
2.	Neoplasms (Cancer)
3.	Gynecomastia
4.	Breast Neoplasms (Breast Cancer)
5.	Prostatic Neoplasms (Prostate Cancer)

Experts

1.	Milias, S: 2 articles (09/2007 - 07/2005)
2.	Kalekou, H: 2 articles (09/2007 - 07/2005)
3.	Kostopoulos, I: 2 articles (09/2007 - 07/2005)
4.	Giordano, Sharon H: 2 articles (07/2006 - 06/2002)
5.	Hortobagyi, Gabriel N: 2 articles (07/2006 - 06/2002)
6.	Carder, P J: 2 articles (02/2006 - 01/2005)
7.	Speirs, V: 2 articles (02/2006 - 01/2005)
8.	Lansdown, M R J: 2 articles (02/2006 - 01/2005)
9.	Brentani, R R: 2 articles (07/2001 - 07/2001)
10.	Nonogaki, S: 2 articles (07/2001 - 07/2001)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Male Breast Neoplasms:

1.	Tamoxifen FDA LinkGeneric 04/01/1979 - "This case, added to others reported, suggests that tamoxifen may be useful in the treatment of advanced male breast cancer. " 01/01/2000 - "A case report of advanced male breast cancer with an objective response to tamoxifen treatment." 07/01/1994 - "Tamoxifen administration is associated with a high rate of treatment-limiting symptoms in male breast cancer patients." 02/01/1992 - "Adjuvant tamoxifen for male breast cancer (MBC)." 02/01/1991 - "[The effect of tamoxifen on the growth of the human male breast cancer cell line (KBC-2)]" Order ALL the reference details at left...
2.	Cyproterone AcetateIBA 05/15/1985 - "Cyproterone acetate is an effective and well-tolerated treatment for metastatic male breast cancer." 01/01/1982 - "These results suggest that cyproterone acetate may be useful in the treatment of advanced male breast cancer." 01/01/1982 - "Cyproterone acetate in advanced male breast cancer." 07/15/1993 - "Combined treatment with buserelin and cyproterone acetate in metastatic male breast cancer." Order ALL the reference details at left...
3.	HormonesIBA 12/01/2007 - "The aim of the present study is to analyse the cases of male breast carcinoma as regards its incidence, family history, clinical presentation, staging, histopathological grade, hormone receptor status and to identify the prognostic significance of the above factors on the final outcome. " 08/01/2009 - "CONCLUSION: In comparison to female patients with breast cancer, male patients are older, and have more advanced and more hormone positive disease." 07/01/2007 - "A concise review of the past, present, and possible future management of hormone-dependent male breast cancer is presented. " 07/01/2007 - "The management of hormone-dependent male breast cancer is insufficiently understood by practicing oncologists. " 07/01/2007 - "Some aspects of the endocrine profile and management of hormone-dependent male breast cancer." Order ALL the reference details at left...
4.	Buserelin (Suprefact)IBA 02/15/1987 - "Androgen deprivation by means of nasally administered buserelin offers an easy and efficient alternate approach in the treatment of metastatic male breast cancer." 02/15/1987 - "Nasally administered buserelin inducing complete remission of lung metastases in male breast cancer." 07/15/1993 - "Combined treatment with buserelin and cyproterone acetate in metastatic male breast cancer." 08/01/1988 - "Advanced male breast cancer treatment with the LH-RH analogue buserelin alone or in combination with the antiandrogen flutamide." Order ALL the reference details at left...
5.	anastrozole (Arimidex)FDA Link 06/01/2002 - "Efficacy of anastrozole in male breast cancer." Order ALL the reference details at left...
6.	CMF regimenIBA 04/01/2006 - "CONCLUSION: Though radiotherapy seems quite effective in reducing local recurrence, we have revealed that male breast cancer patients in our cohort with extensive nodal involvement (PPNI >30% and 50%) appeared not to have had a significant benefit from postmastectomy irradiation and adjuvant CMF-based chemotherapy." Order ALL the reference details at left...
7.	Estrogens (Estrogen)FDA Link 05/28/1977 - "The authors study estrogen (RE) and progestogen (RP) receptors by an exchange technique in 8 cases of male breast carcinoma and 7 cases of gynaecomastia. " 06/01/2007 - "Three of 4 male breast tumors with BRCA1 mutations (75%) were estrogen receptor positive. " 12/01/2004 - "Many features of male breast carcinoma in Jordan (symptomatology, male to female ratio, high education rate, age, diagnostic yield of fine-needle aspiration, histological type, and estrogen receptor status) did not depart from the experience of others. " 03/01/2004 - "The possible role of estrogen in the development of male breast cancer is revisited." 01/01/1997 - "Retrospective case-control studies indicate that both estrogen excess and androgen deficiency may be involved in male breast cancer. " Order ALL the reference details at left...
8.	Progesterone Receptors (Progesterone Receptor)IBA 02/01/1998 - "We report, for the first time, a high frequency of LOH at chromosome 13q12-13 in sporadic male breast cancer and its association with factors indicating a poor prognosis for this tumor (e.g., lymph node metastasis and negative progesterone receptor status). " 05/01/2000 - "The prognostic role of ploidy status, S phase fraction, estrogen and progesterone receptor status, and the expression of p53 and erbB-2 protein in male breast carcinoma (MBC) remains controversial. " 11/01/1982 - "Cytoplasmic and nuclear estrogen and progesterone receptors in male breast cancer." 04/01/1980 - "Nine of 14 male breast cancer patients had positive progesterone receptor assays and several had androgen or glucocorticoid receptors. " 08/01/2002 - "The aim of this study is to evaluate the expression patterns of estrogen receptor (ER), progesterone receptor (PR), MiB1 (Ki67), Her-2/neu (c-erbB2), and p53 and to correlate them with the prognosis, presentation, staging, management, and survival/outcome in male breast carcinoma identified through the Veterans Administration nationwide cancer registry. " Order ALL the reference details at left...
9.	DNA (Deoxyribonucleic Acid)IBA 01/01/1994 - "Studies based on extended materials are necessary to further investigated the role of DNA analysis as a predictor of outcome in male breast cancer patients." 12/01/2004 - "DNA was isolated from male breast cancer biopsies, and the AR CAG repeat sized. " 12/15/2003 - "The restoration assays show that AR NH2-terminal/DNA-binding domain, but not the ligand-binding domain, is essential for normal MAPK function in MCF7 cells, and an AR mutant (R608K), found in male breast cancer, is associated with the excessive activation of MAPK. " 11/20/2000 - "Nuclear morphometry in male breast carcinoma: association with cell proliferative activity, oncogene expression, DNA content and prognosis." 07/01/1996 - "Quantitative parameters, such as DNA ploidy, p53 scores, AgNOR counts, PC10, and MIB-1 scores substantially improve the prognostic significance of the traditional parameters in male breast carcinoma." Order ALL the reference details at left...
10.	ParaffinIBA 07/01/2001 - "The purpose of the present study was to analyze the expression of the oncogenes c-erbB-2 and c-myc and of the suppressor gene p53 by immunohistochemical techniques in archival paraffin-embedded tissue blocks of 48 male breast cancer patients, treated at the A.C. " 08/01/1992 - "The presence of neuroendocrine differentiation, as expressed by cellular chromogranin immunoreactivity, was investigated in paraffin-embedded tissue material from 51 consecutive cases of male breast carcinoma. " 03/01/2002 - "In this study we have examined DNA extracted from paraffin tissue from 15 patients treated for male breast cancer, for evidence of such abnormalities, at 20 different loci across the genome. " 01/01/1992 - "We have studied 21 cases of male breast carcinoma immunohistochemically for oestrogen receptor (ER) and epidermal growth factor receptor (EGFR) expression employing the antibodies ER-ICA and 12E on formalin-fixed, paraffin-embedded material. " 08/01/1994 - "The proliferative activity of male breast carcinoma has been investigated using the staining of the argyrophilic nucleolar organizer regions (AgNORs), the monoclonal antibody against the proliferating cell nuclear antigen (PC10) and the monoclonal antibody MIB-1 in formalin-fixed, paraffin-embedded specimens from 27 primary male breast carcinomas at diagnosis. " Order ALL the reference details at left...

Therapies and Procedures

1.	Drug Therapy (Chemotherapy) 06/01/2002 - "Pharmacotherapy for male breast cancer." 02/01/1995 - "Treatment of locally recurrent male breast cancer by regional chemotherapy." 01/01/1989 - "Immunohistochemical investigation in male breast cancer patients was valuable in the selection of post-operative adjuvant endocrine therapy or chemotherapy. " 01/01/1985 - "Chemotherapy in metastatic male breast cancer." 06/01/1983 - "In this paper, the problematic aspects of ER such as the molecular forms, inter-site variations, relationships to histological pattern, with regard to the effectiveness of chemotherapy and to prognosis, and ER in male breast cancer, are reviewed and discussed." Order ALL the reference details at left...
2.	Mastectomy (Mammectomy) 11/01/2002 - "BACKGROUND AND PURPOSE: Previous studies of male breast cancer have suggested that due to the lack of breast tissue, post-mastectomy radiation should be routinely utilized in all stages of this disease. " 01/01/2009 - "Furthermore, genetic testing and risk-reducing mastectomy should also be considered in cases of a strong family history for male breast cancer." 05/01/2007 - "Mastectomy with axillary dissection is still the most commonly recommended procedure for male breast cancer. " 01/01/2007 - "Male breast cancer in a young patient treated with nipple-sparing mastectomy: case report and review of the literature." 11/01/2002 - "Post-mastectomy radiation in male breast cancer." Order ALL the reference details at left...
3.	Orchiectomy (Orchidectomy) 05/01/1981 - "This review supports the importance of orchiectomy in the treatment of metastatic male breast cancer. " 02/01/1976 - "The role of orchiectomy in the management of advanced male breast cancer." 01/01/1984 - "Tamoxifen response following no response to orchiectomy in metastatic male breast cancer: a case report." 10/01/1982 - "Tamoxifen before and after orchiectomy in advanced male breast cancer." 01/01/1976 - "Male breast cancer: two cases with objective regressions from calusterone (7 alpha, 17 beta-dimethyltestosterone) after failure of orchiectomy." Order ALL the reference details at left...
4.	Adjuvant Chemotherapy 06/01/2007 - "Adjuvant chemotherapy may benefit male breast cancer patients with positive nodes." 06/01/2007 - "CONCLUSION: To our knowledge, 20-year prospective data with adjuvant chemotherapy in male breast cancer has never been reported. " 10/15/1989 - "Role of adjuvant chemotherapy in male breast cancer." 03/20/2007 - "RESULTS: Of 510 male breast cancer cases (456 white, 34 black), 94% underwent mastectomy, 28% received adjuvant chemotherapy, and 29% received radiation therapy. " 09/01/1990 - "In light of the encouraging results about adjuvant chemotherapy in the treatment for female breast cancer with axillary lymph node involvement, it would be desirable to extend this policy to male breast cancer." Order ALL the reference details at left...
5.	Modified Radical Mastectomy (Mastectomy, Modified) 12/01/2007 - "Male breast cancer in general is treated by modified radical mastectomy. " 01/01/2005 - "CONCLUSION: Modified radical mastectomy followed by external radiation therapy is the standard treatment for male breast cancer. " 05/01/1993 - "We conclude that radical or modified radical mastectomy is the rational therapy for male breast cancer. " 05/01/1998 - "CONCLUSION: The optimal treatment for male breast carcinoma is modified radical mastectomy combined with radiotherapy, chemotherapy and endocrine therapy." Order ALL the reference details at left...

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