Expression of rhesus blood group antigens in HTLV-i infection in northeast Iran.
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| Abstract | BACKGROUND: Human T-cell lymphoma/leukemia virus type 1 (HTLV-1) infection is relatively common in northeast Iran. It is important to understand which factors play a role in the pathogenesis of this virus. Blood group antigens may act as a receptor for various infectious agents. This study was performed to detect any association between Rh blood group antigens and HTLV-1 infection in northeast Iran. METHODS: In this case and control study, Rhesus blood group antigens (D, C, c, E and e) were determined within 24 hours of blood collection by commercial antibodies in 100 HTLV-I infected individuals and 332 healthy blood donors at the Khorasan Blood Transfusion Center, Mashhad, Iran, in 2011. The results of HTLV-I positive subjects and the control group were compared using SPSS software. RESULTS: The frequencies of Rh blood group antigens in the case group were D in 88%, C in 72%, c in 68%, E in 27%, and e in 94%. In the control group the frequencies were D in 91%, C in 75.5%, c in 72.9%, E in 28.6% and e in 98.2%. Chi-square test showed a significant difference between the two groups for the frequency of e antigen (p = 0.03). CONCLUSIONS: Our study showed that e antigen expression is associated with a decreased risk of HTLV-I infection in northeast Iran.
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| Authors | Mohammad Hadi Sadeghian, Mohammad Reza Keramati, Hossein Ayatollahi, Atefeh Shirinzadeh-Feizabadi, Fatemeh Sobhani, Farahnaz Tehranaian, Hossein Shakibaie |
| Journal | Clinical laboratory (Clin Lab) Vol. 58 Issue 11-12 Pg. 1323-7 ( 2012) ISSN: 1433-6510 [Print] Germany |
| PMID | 23289207 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't) |
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