Abstract | UNLABELLED: BACKGROUND: METHODS: Patients with serial quantitative serum immunoglobulin (SIgG) concentrations before and subsequent to rituximab administration at Memorial Sloan-Kettering Cancer Center were identified. Information regarding rituximab administration, SIgG concentrations, frequency of infection, and administration of IVIG were recorded. RESULTS: Between December 1998 and April 2009, 211 patients with B-cell lymphoma treated with rituximab and with serial SIgG concentrations were identified. One hundred seventy-nine (85%) patients had normal SIgG before rituximab, 32 (15%) had low SIgG. After rituximab use, hypogammaglobulinemia was identified in 38.54% of patients with initially normal SIgG. The risk was greater in patients who received maintenance rituximab. Symptomatic hypogammaglobulinemia that prompted IVIG administration developed in 6.6% of patients. CONCLUSIONS:
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Authors | Carla Casulo, Jocelyn Maragulia, Andrew D Zelenetz |
Journal | Clinical lymphoma, myeloma & leukemia
(Clin Lymphoma Myeloma Leuk)
Vol. 13
Issue 2
Pg. 106-11
(Apr 2013)
ISSN: 2152-2669 [Electronic] United States |
PMID | 23276889
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2013 Elsevier Inc. All rights reserved. |
Chemical References |
- Antibodies, Monoclonal, Murine-Derived
- Antineoplastic Agents
- Immunoglobulin A
- Immunoglobulin G
- Immunoglobulin M
- Immunoglobulins, Intravenous
- Rituximab
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Topics |
- Adolescent
- Adult
- Agammaglobulinemia
(complications, etiology, therapy)
- Aged
- Aged, 80 and over
- Antibodies, Monoclonal, Murine-Derived
(adverse effects, therapeutic use)
- Antineoplastic Agents
(adverse effects, therapeutic use)
- Child
- Humans
- Immunoglobulin A
(blood, immunology)
- Immunoglobulin G
(blood, immunology)
- Immunoglobulin M
(blood, immunology)
- Immunoglobulins, Intravenous
(administration & dosage)
- Incidence
- Infections
(etiology, therapy)
- Lymphoma, B-Cell
(complications, drug therapy)
- Middle Aged
- Rituximab
- Young Adult
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