Prognostic role of clusterin in resected adenocarcinomas of the lung.

Abstract

RATIONALE:

Clusterin expression may change in various human malignancies, including lung cancer. Patients with resectable non-small cell lung cancer (NSCLC), including adenocarcinoma, have a poor prognosis, with a relapse rate of 30-50% within 5 years. Nuclear factor kB (Nf-kB) is an intracellular protein involved in the initiation and progression of several human cancers, including the lung.

OBJECTIVES:

We investigate the role of clusterin and Nf-kB expression in predicting the prognosis of patients with early-stage surgically resected adenocarcinoma of the lung.

FINDINGS:

The level of clusterin gradually decreased from well-differentiated to poorly differentiated adenocarcinomas. Clusterin expression was significantly higher in patients with low-grade adenocarcinoma, in early-stage disease and in women. Clusterin expression was inversely related to relapse and survival in both univariate and multivariate analyses. Finally, we observed an inverse correlation between Nf-kB and clusterin.

CONCLUSIONS:

Clusterin expression represents an independent prognostic factor in surgically resected lung adenocarcinoma and was proven to be a useful biomarker for fewer relapses and longer survival in patients in the early stage of disease. The inverse correlation between Nf-kB and clusterin expression confirm the previously reported role of clusterin as potent down regulator of Nf-kB.

• Authors: Francesca Panico, Christian Casali, Giulio Rossi, Federica Rizzi, Uliano Morandi, Saverio Bettuzzi, Pierpaola Davalli, Lorenzo Corbetta, Erica Susanna Storelli, Arnaldo Corti, Leonardo M Fabbri, Serenella Astancolle, Fabrizio Luppi
• Journal: Lung cancer (Amsterdam, Netherlands) (Lung Cancer) Vol. 79 Issue 3 Pg. 294-9 (Mar 2013) ISSN: 1872-8332 [Electronic] Ireland
• PMID: 23276503 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.

Chemical References

• Biomarkers, Tumor
• Clusterin
• NF-kappa B

Topics

• Adenocarcinoma (diagnosis, mortality, surgery)
• Adult
• Aged
• Aged, 80 and over
• Biomarkers, Tumor (genetics)
• Clusterin (genetics, metabolism)
• Female
• Humans
• Lung (metabolism, pathology, surgery)
• Lung Neoplasms (diagnosis, mortality, surgery)
• Male
• Middle Aged
• NF-kappa B (genetics, metabolism)
• Neoplasm Staging
• Predictive Value of Tests
• Prognosis
• Survival Analysis