Study on SSAO enzyme activity and anti-inflammatory effect of SSAO inhibitors in animal model of inflammation.

Abstract

SSAO/VAP-1 participates in the accumulation of leukocytes at the site of inflammation. A new SSAO inhibitor, SzV-1287 was demonstrated to inhibit both acute and chronic inflammation in rats more effectively than the known enzyme inhibitor, LJP-1207. Surprisingly, the SSAO activity was not increased, but decreased both in acute and chronic inflammation. Though experiments are in progress to clarify these findings, the enzyme might play a role in the very early phase of inflammation and be inactivated during leukocyte extravasation.

• Authors: Tamás Tábi, Eva Szökő, Anita Mérey, Veronika Tóth, Péter Mátyus, Klára Gyires
• Journal: Journal of neural transmission (Vienna, Austria : 1996) (J Neural Transm (Vienna)) Vol. 120 Issue 6 Pg. 963-7 (Jun 2013) ISSN: 1435-1463 [Electronic] Austria
• PMID: 23263543 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• 3-(4,5-diphenyl-1,3-oxazol-2-yl)propanal oxime
• Enzyme Inhibitors
• Hydrazines
• N'-(2-phenylallyl)hydrazine
• Oxazoles
• Oximes
• Carrageenan
• Amine Oxidase (Copper-Containing)

Topics

• Amine Oxidase (Copper-Containing) (metabolism)
• Animals
• Arthritis, Experimental (chemically induced, drug therapy)
• Carrageenan (toxicity)
• Disease Models, Animal
• Enzyme Inhibitors (therapeutic use)
• Functional Laterality
• Gene Expression Regulation, Enzymologic (drug effects)
• Hydrazines (therapeutic use)
• Inflammation (chemically induced, drug therapy, ethnology)
• Male
• Oxazoles (therapeutic use)
• Oximes (therapeutic use)
• Rats
• Rats, Wistar
• Time Factors