A multifunctional heptamethine near-infrared dye for cancer theranosis.

Abstract

Personalized oncology significantly relies on the development of cancer theranostic agents to integrate cancer therapeutics and diagnostics. Current most common strategy for development of such multifunctional agents requires multistep chemical conjugation with cancer targeted ligands, contrast agents and therapeutic agents. Here we report the chemical synthesis and biological characterization of a new heptamethine dye, termed as IR-808DB, natively with multifunctional characteristics of cancer targeting, near-infrared fluorescence imaging, and efficient anticancer activity. The tumor inhibition effect of IR-808DB is higher than that of cyclophosphamide (CTX) toward a broad spectrum of tumor xenograft models. These findings provide IR-808DB a promising prospect as a new cancer theranostic agent that would enable integration of cancer targeted therapeutics and diagnostics without requirement of multi-component chemical conjugation.

• Authors: Shenglin Luo, Xu Tan, Qingrong Qi, Qinyuan Guo, Xinze Ran, Lilong Zhang, Erlong Zhang, Yufeng Liang, Lingling Weng, Hu Zheng, Tianmin Cheng, Yongping Su, Chunmeng Shi
• Journal: Biomaterials (Biomaterials) Vol. 34 Issue 9 Pg. 2244-51 (Mar 2013) ISSN: 1878-5905 [Electronic] Netherlands
• PMID: 23261220 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2012 Elsevier Ltd. All rights reserved.

Chemical References

• Antineoplastic Agents
• Carbocyanines
• Contrast Media
• Fluorescent Dyes
• IR-808DB
• Indoles

Topics

• Animals
• Antineoplastic Agents (pharmacology)
• Carbocyanines (chemistry, therapeutic use)
• Cells, Cultured
• Contrast Media (chemistry, therapeutic use)
• Diagnostic Imaging (methods)
• Fluorescent Dyes (chemistry, therapeutic use)
• HeLa Cells
• Humans
• Indoles (chemistry, therapeutic use)
• Male
• Mice
• Mice, Inbred C57BL
• Mice, Nude
• Neoplasms (diagnosis)
• Rats
• Rats, Sprague-Dawley
• Xenograft Model Antitumor Assays