Antiviral activity of (+)-sattabacin against varicella zoster.

Abstract

The first report of the antiviral activity of (+)-sattabacin against varicella-zoster virus (VZV) is described. Our results show that (+)-sattabacin potently inhibits the growth of VZV at concentrations in the range of other drugs commonly prescribed for VZV infection. Experiments detailing the synthesis of (+)-sattabacin, quantification of cytotoxicity and gene expression data in human fibroblast cells are also presented. Gene expression data was obtained through microarray analysis from human fibroblast cells exposed to sattabacin in order to identify a possible mechanism by which (+)-sattabacin inhibits VZV replication.

• Authors: Serena R Mancha, Christopher M Regnery, Joshua R Dahlke, Kenneth A Miller, David J Blake
• Journal: Bioorganic & medicinal chemistry letters (Bioorg Med Chem Lett) Vol. 23 Issue 2 Pg. 562-4 (Jan 15 2013) ISSN: 1464-3405 [Electronic] England
• PMID: 23219702 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2012 Elsevier Ltd. All rights reserved.

Chemical References

• Antiviral Agents
• Hexanones
• sattabacin

Topics

• Antiviral Agents (chemistry, pharmacology)
• Cell Survival (drug effects)
• Cells, Cultured
• Herpesvirus 3, Human (drug effects)
• Hexanones (chemical synthesis, chemistry, pharmacology)
• Humans
• Molecular Structure