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Antiinflammatory activity of flavonoids.

Abstract
Fourteen flavonoids (flavones,- flavanones and chalcones) were assayed for oral antiinflammatory activity using carrageenan-induced hind paw edema in rats. The structural features necessary for antiinflammatory activity appear to be the presence of methoxyl groups at C5 and C7 of ring A and the pyrano ring B of the flavonoid molecule. Negligible or low antiinflammatory activities were found in the chalcone derivatives. The difference in the efficacy of the flavonoids tested possibly depends on their pharmacokinetic properties.
AuthorsA Panthong, D Kanjanapothi, P Tuntiwachwuttikul, O Pancharoen, V Reutrakul
JournalPhytomedicine : international journal of phytotherapy and phytopharmacology (Phytomedicine) Vol. 1 Issue 2 Pg. 141-4 (Sep 1994) ISSN: 0944-7113 [Print] Germany
PMID23195887 (Publication Type: Journal Article)
CopyrightCopyright © 1994 Gustav Fischer Verlag, Stuttgart · Jena · New York. Published by Elsevier GmbH.. All rights reserved.

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