Abstract |
Fourteen flavonoids ( flavones,- flavanones and chalcones) were assayed for oral antiinflammatory activity using carrageenan-induced hind paw edema in rats. The structural features necessary for antiinflammatory activity appear to be the presence of methoxyl groups at C5 and C7 of ring A and the pyrano ring B of the flavonoid molecule. Negligible or low antiinflammatory activities were found in the chalcone derivatives. The difference in the efficacy of the flavonoids tested possibly depends on their pharmacokinetic properties.
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Authors | A Panthong, D Kanjanapothi, P Tuntiwachwuttikul, O Pancharoen, V Reutrakul |
Journal | Phytomedicine : international journal of phytotherapy and phytopharmacology
(Phytomedicine)
Vol. 1
Issue 2
Pg. 141-4
(Sep 1994)
ISSN: 0944-7113 [Print] Germany |
PMID | 23195887
(Publication Type: Journal Article)
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Copyright | Copyright © 1994 Gustav Fischer Verlag, Stuttgart · Jena · New York. Published by Elsevier GmbH.. All rights reserved. |