Abstract | OBJECTIVE:
Pleural tuberculosis is the most frequently occurring form of extra pulmonary disease in adults. In up to 40% of cases, the lung parenchyma is concomitantly involved, which can have an epidemiological impact. This study aims to evaluate the pleural and systemic inflammatory response of patients with pleural or pleuropulmonary tuberculosis. METHODS: RESULTS: CONCLUSION:
Tumor necrosis factor-α was the single cytokine that significantly increased in the pleural fluid of the patients with pulmonary involvement. However, an overlap in the results does not permit us to suggest that cytokine is a biological marker of concomitant parenchymal involvement. Although high resolution chest tomography can be useful in identifying these patients, the investigation of fast acid bacilli and cultures for M. tuberculosis in the sputum is recommended for all patients who are diagnosed with pleural tuberculosis.
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Authors | Leila Antonangelo, Francisco S Vargas, Juliana Puka, Márcia Seiscento, Milena M P Acencio, Lisete R Teixeira, Ricardo M Terra, Roberta K B Sales |
Journal | Clinics (Sao Paulo, Brazil)
(Clinics (Sao Paulo))
Vol. 67
Issue 11
Pg. 1259-63
(Nov 2012)
ISSN: 1980-5322 [Electronic] United States |
PMID | 23184200
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Biomarkers
- Cytokines
- Transforming Growth Factor beta1
- Tumor Necrosis Factor-alpha
- Vascular Endothelial Growth Factor A
- Oxidoreductases
- Adenosine Deaminase
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Topics |
- Adenosine Deaminase
(analysis)
- Adult
- Biomarkers
(analysis)
- Cytokines
(analysis)
- Disease Progression
- Enzyme-Linked Immunosorbent Assay
- Exudates and Transudates
(chemistry)
- Humans
- Middle Aged
- Oxidoreductases
(analysis)
- Pleural Effusion
(diagnostic imaging, metabolism)
- Prospective Studies
- Radiography
- Transforming Growth Factor beta1
(analysis)
- Tuberculosis, Pleural
(diagnostic imaging, metabolism)
- Tuberculosis, Pulmonary
(metabolism)
- Tumor Necrosis Factor-alpha
(analysis)
- Vascular Endothelial Growth Factor A
(analysis)
- Young Adult
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