The miRNAs of herpes simplex virus (HSV).

Abstract

Herpes simplex virus (HSV) is a group of common human pathogens with two serotypes HSV-1 and HSV-2. The prevalence of HSV is worldwide. It primarily infects humans through epithelial cells, when it introduces a latent infection into the nervous system. During viral latency, only a region known as the latency-associated transcript (LAT) is expressed. The discovery of HSV miRNAs helps to draw a larger picture of the infection and pathogenesis of the virus. This review summarizes miRNAs found in HSV-1 and HSV-2 so far. The functional studies of miRNAs in HSV to date indicate that they play a stage-specific role coordinated with viral proteins to maintain the virus life cycle.

• Authors: Le Sun, Qihan Li
• Journal: Virologica Sinica (Virol Sin) Vol. 27 Issue 6 Pg. 333-8 (Dec 2012) ISSN: 1995-820X [Electronic] Netherlands
• PMID: 23180288 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)

Chemical References

• MicroRNAs
• RNA, Viral

Topics

• Gene Expression Regulation, Viral
• Humans
• MicroRNAs (genetics, metabolism)
• RNA, Viral (genetics, metabolism)
• Simplexvirus (genetics, physiology)
• Virus Latency
• Virus Replication