Association of interleukin-18 promoter polymorphisms with chronic obstructive pulmonary disease in male smokers.

Abstract

Chronic obstructive pulmonary disease (COPD) is considered a complex genetic disorder and it is expected that many genes play a role in the pathogenesis of this disease. Previous studies have reported that several variations within the interleukin (IL)-18 gene promoter region have been associated with different inflammatory diseases such as asthma. However, the association of IL-18 promoter polymorphisms with COPD has not been studied yet. We then performed a prospective case-control study to explore this association in male smokers of Chinese Han people. Our study recruited 112 COPD cases and 105 healthy controls matched for age. The genotyping of IL-18 promoter polymorphisms (-607 C/A and -137 G/C) was performed using TaqMan single nucleotide polymorphism genotyping assays. The frequencies of the alleles and genotypes in patients and controls were compared. We found that the frequency of IL-18 -607 C allele was significantly increased in patients with COPD (odds ratio (OR) = 1.48, 95% confidence interval (CI) = 1.01-2.15, P = 0.04). The frequency of IL-18 -607 C allele was significantly higher in the GOLD (Global initiative for Obstructive Lung Disease) 3-4 group compared with the GOLD 1-2 group (OR=2.06, 95% CI = 1.21-3.51, P = 0.01). There were no significant differences in the frequencies of the alleles and genotypes of IL-18 -137 G/C polymorphism between the patients and healthy smokers or between GOLD 3-4 group and GOLD 1-2 group. Our study revealed that the IL-18 -607 C/A polymorphism was associated with COPD susceptibility and severity of airflow limitation in male smokers of Chinese Han people.

• Authors: J Wang, X Liu, J Xie, Y Xu
• Journal: International journal of immunogenetics (Int J Immunogenet) Vol. 40 Issue 3 Pg. 204-8 (Jun 2013) ISSN: 1744-313X [Electronic] England
• PMID: 23171362 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2012 Blackwell Publishing Ltd.

Chemical References

• Interleukin-18

Topics

• Aged
• Asian People (genetics)
• Case-Control Studies
• China
• Gene Frequency
• Genetic Association Studies
• Genotype
• Humans
• Interleukin-18 (genetics)
• Male
• Middle Aged
• Polymorphism, Genetic
• Promoter Regions, Genetic
• Prospective Studies
• Pulmonary Disease, Chronic Obstructive (genetics, physiopathology)
• Respiratory Function Tests
• Smoking