Primary diffuse large B-Cell lymphoma of the prostate presenting with urinary retention and dyschezia for which rituximab-combined CHOP therapy was effective-a case presentation.

Abstract

We report the case of a 66-year-old man with primary diffuse large B-cell lymphoma of the prostate presenting with urinary retention and dyschezia as first manifestation. Although a colostomy was needed due to rectal obstruction, rituximab-combined chemotherapy resulted in complete remission. He underwent stoma closure safely and has remained in complete remission for over 3years. Primary prostatic lymphoma is extremely rare, presenting as 0.1% of newly diagnosed lymphomas, but rituximab-containing chemotherapy seems to be as effective as for nodal lymphoma.

• Authors: Masahiro Manabe, Yoshiki Hayashi, Yumi Yoshii, Satoru Mukai, Erina Sakamoto, Hiroshi Kanashima, Takafumi Nakao, Takuma Hayama, Hiroko Fukushima, Takeshi Inoue, Takahisa Yamane, Hirofumi Teshima
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 39 Issue 11 Pg. 1733-5 (Nov 2012) ISSN: 0385-0684 [Print] Japan
• PMID: 23152030 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antibodies, Monoclonal, Murine-Derived
• Rituximab
• Vincristine
• Doxorubicin
• Cyclophosphamide
• Prednisone

Topics

• Aged
• Antibodies, Monoclonal, Murine-Derived (administration & dosage, therapeutic use)
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Combined Modality Therapy
• Constipation (etiology)
• Cyclophosphamide (therapeutic use)
• Doxorubicin (therapeutic use)
• Humans
• Lymphoma, Large B-Cell, Diffuse (complications, drug therapy, pathology, surgery)
• Male
• Prednisone (therapeutic use)
• Prostate (pathology)
• Rectal Neoplasms (complications, drug therapy, pathology, surgery)
• Remission Induction
• Rituximab
• Urinary Retention (etiology)
• Vincristine (therapeutic use)