IsoDGR-tagged albumin: a new αvβ3 selective carrier for nanodrug delivery to tumors.

Abstract

A new cyclic peptide containing the isoDGR motif that, after coupling to albumin, selectively binds αvβ3, an integrin overexpressed in the tumor vasculature. IsoDGR-tagged albumin binds tumor vessels and can be exploited as a carrier for the preparation of tumor vasculature-selective nanomedicines, such as gold nanoparticles (Au) carrying tumor necrosis factor α (TNF), a potent vascular damaging agent.

• Authors: Flavio Curnis, Angelina Sacchi, Renato Longhi, Barbara Colombo, Anna Gasparri, Angelo Corti
• Journal: Small (Weinheim an der Bergstrasse, Germany) (Small) Vol. 9 Issue 5 Pg. 673-8 (Mar 11 2013) ISSN: 1613-6829 [Electronic] Germany
• PMID: 23143930 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Chemical References

• Integrin alphaVbeta3
• Tumor Necrosis Factor-alpha
• Gold

Topics

• Gold (chemistry)
• Humans
• Integrin alphaVbeta3 (administration & dosage, chemistry)
• Metal Nanoparticles (chemistry)
• Neoplasms (metabolism)
• Tumor Necrosis Factor-alpha (chemistry)