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Tin-mesoporphyrin in the treatment of refractory hyperbilirubinemia due to Rh incompatibility.

Abstract
We describe the use of tin-mesoporphyrin (SnMP) in the treatment of an infant with Rh hemolytic disease. The infant's hyperbilirubinemia responded to phototherapy but every time the phototherapy was discontinued, the serum bilirubin rebounded and repeat phototherapy was necessary. A single intramuscular dose of SnMP on day 18 eliminated the need for further phototherapy and allowed us to discharge this infant.
AuthorsM J Maisels, H Yang
JournalJournal of perinatology : official journal of the California Perinatal Association (J Perinatol) Vol. 32 Issue 11 Pg. 899-900 (Nov 2012) ISSN: 1476-5543 [Electronic] United States
PMID23128060 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Enzyme Inhibitors
  • Metalloporphyrins
  • tin mesoporphyrin
  • Heme Oxygenase (Decyclizing)
Topics
  • Adult
  • Combined Modality Therapy
  • Enzyme Inhibitors (therapeutic use)
  • Erythroblastosis, Fetal (drug therapy)
  • Heme Oxygenase (Decyclizing) (antagonists & inhibitors)
  • Humans
  • Hyperbilirubinemia
  • Male
  • Metalloporphyrins (therapeutic use)
  • Retreatment

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