eNOS genotype modifies the effect of leisure-time physical activity on serum triglyceride levels in a Japanese population.

Abstract

BACKGROUND:

Nitric oxide is a key molecule not only in the cardiovascular system, but also in the metabolic-endocrine system. The purpose of this study was to examine possible associations of the NOS3 T-786C polymorphism (rs2070744) with serum lipid levels on the basis of lifestyle factors for tailoring prevention of dyslipidemia.

METHODS:

For this cross-sectional study, a total of 2226 subjects aged 35 to 69 years (1084 men and 1142 women) were selected from Japanese participants in the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study. They were recruited in eight areas throughout Japan between February 2004 and November 2008.

RESULTS:

In a stratified analysis by leisure-time physical activity, the likelihood of hypertriglyceridemia (serum triglyceride levels ≥ 150 mg/dL) among subjects with the C allele was significantly lower than those without it in the active group (OR = 0.43, 95% CI = 0.22-0.84 in the fasting group), but not in the sedentary group. A gene-environment interaction between the T-786C polymorphism and leisure-time physical activity for hypertriglyceridemia was significant (P = 0.007 in the fasting group). Additionally, serum triglyceride levels (mean ± SD) across leisure-time physical activity classes decreased significantly only in the TC + CC genotype group (111 ± 60 mg/dL for sedentary, 95 ± 48 mg/dL for moderately active, 88 ± 44 mg/dL for very active, P for trend = 0.008 in the fasting group), but not in the TT genotype group. Total cholesterol, high-density lipoprotein (HDL) cholesterol, and non-HDL cholesterol levels had no significant association with the polymorphism.

CONCLUSIONS:

This study suggests that the NOS3 T-786C polymorphism modifies the effect of leisure-time physical activity on serum triglyceride levels.

• Authors: Takahiro Higashibata, Nobuyuki Hamajima, Mariko Naito, Sayo Kawai, Guang Yin, Sadao Suzuki, Yoshikuni Kita, Hideshi Niimura, Takeshi Imaizumi, Keizo Ohnaka, Kokichi Arisawa, Masako Shigeta, Hidemi Ito, Haruo Mikami, Michiaki Kubo, Hideo Tanaka, Kenji Wakai
• Journal: Lipids in health and disease (Lipids Health Dis) Vol. 11 Pg. 150 (Nov 05 2012) ISSN: 1476-511X [Electronic] England
• PMID: 23122449 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Triglycerides
• NOS3 protein, human
• Nitric Oxide Synthase Type III

Topics

• Adult
• Aged
• Alleles
• Dyslipidemias (genetics, physiopathology)
• Female
• Genetic Association Studies
• Humans
• Japan
• Leisure Activities
• Male
• Middle Aged
• Motor Activity
• Nitric Oxide Synthase Type III (blood, genetics)
• Polymorphism, Single Nucleotide
• Risk Factors
• Triglycerides (blood, genetics)