Abstract | PURPOSE: EXPERIMENTAL DESIGN: RESULTS: Treatment of cells in culture and tumor-bearing animals with cisplatin resulted in activation of AKT, a key mediator of cell survival. On the basis of these results, we investigated the therapeutic use of AKT inhibition in combination with cisplatin, which resulted in enhanced and prolonged induction of apoptosis and in significantly improved tumor control as compared with either agent alone. CONCLUSION: These results provide an impetus for clinical trials using combination therapy. To facilitate these trials, we also show the use of diffusion-weighted MRI as an imaging biomarker for evaluation of therapeutic efficacy in OEA.
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Authors | Hanxiao Wang, Stefanie Galbán, Rong Wu, Brittany M Bowman, Amanda Witte, Katrin Vetter, Craig J Galbán, Brian D Ross, Kathleen R Cho, Alnawaz Rehemtulla |
Journal | Clinical cancer research : an official journal of the American Association for Cancer Research
(Clin Cancer Res)
Vol. 19
Issue 1
Pg. 158-69
(Jan 01 2013)
ISSN: 1557-3265 [Electronic] United States |
PMID | 23095324
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, U.S. Gov't, Non-P.H.S.)
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Chemical References |
- Antineoplastic Agents
- Proto-Oncogene Proteins c-akt
- Cisplatin
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Topics |
- Animals
- Antineoplastic Agents
(administration & dosage, pharmacology)
- Apoptosis
(drug effects)
- Carcinoma, Endometrioid
(drug therapy, genetics, metabolism)
- Cell Line, Tumor
- Cisplatin
(administration & dosage, pharmacology)
- Disease Models, Animal
- Drug Resistance, Neoplasm
(genetics)
- Female
- Magnetic Resonance Imaging
- Mice
- Mice, Transgenic
- Molecular Imaging
- Ovarian Neoplasms
(drug therapy, genetics, metabolism)
- Proto-Oncogene Proteins c-akt
(antagonists & inhibitors, genetics, metabolism)
- Transplantation, Homologous
- Tumor Microenvironment
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