Peripheral nerve injury decreases the expression of metabolic glutamate receptor 7 in dorsal root ganglion neurons.

Abstract

Group II and III metabolic glutamate receptors (mGluRs) are responsible for the glutamate-mediated postsynaptic excitation of neurons. Previous pharmacological evidences show that activation of mGluR7 could inhibit nociceptive reception. However, the distribution and expression patterns of mGluR7 after peripheral injury remain unclear. Herein we found that mGluR7 was expressed in the rat peptidergic dorsal root ganglion (DRG) neurons and large neurons, but rarely in isolectin B4 positive neurons. Sciatic nerve ligation experiment showed that mGluR7 was anterogradely transported from cell body to the peripheral site. Furthermore, after peripheral nerve injury, mGluR7 expression was down-regulated in both peptidergic and large DRG neurons. Our work suggests that mGluR7 might be involved in the regulation of pathological pain after peripheral nerve injury.

• Authors: Jian-You Li, Xiang Wang, Peng-Tian Ji, Xiong-Feng Li, Guo-Hua Guan, Xue-Sheng Jiang, Guo-Shun Zhou, Feng Hua, Nan Wang
• Journal: Neuroscience letters (Neurosci Lett) Vol. 531 Issue 1 Pg. 52-6 (Nov 30 2012) ISSN: 1872-7972 [Electronic] Ireland
• PMID: 23085525 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.

Chemical References

• Receptors, Metabotropic Glutamate
• metabotropic glutamate receptor 7

Topics

• Animals
• Down-Regulation
• Ganglia, Spinal (metabolism)
• Male
• Neurons (metabolism)
• Peripheral Nerve Injuries (metabolism)
• Rats
• Rats, Sprague-Dawley
• Receptors, Metabotropic Glutamate (metabolism)
• Sciatic Nerve (injuries)