Effective use of methylprednisolone aceponate 0.1% in a 9-month-old infant with atopic eczema and sleep disturbance.

Abstract

A 9-month-old infant, with no family history of atopy, presenting with erythematous, itchy plaques, and sleep disturbance, was diagnosed with atopic eczema (AE). Previous treatment with topical hydrocortisone and emollients had little effect. The infant was treated nightly with methylprednisolone aceponate (MPA) 0.1% (Advantan(®)) cream, in addition to emollients and an oral antihistamine. After 1 week of once-daily MPA 0.1% treatment, followed by 1 week of alternate-day treatment with Advantan, significant improvements in AE symptoms and sleep were observed. The patient's caregiver reported overall treatment satisfaction and no side effects of Advantan. For this infant with newly diagnosed AE, Advantan improved symptoms and sleep quality in a safe and well-tolerated manner.

• Authors: S Machado
• Journal: Journal of the European Academy of Dermatology and Venereology : JEADV (J Eur Acad Dermatol Venereol) Vol. 26 Suppl 6 Pg. 14-5 (Nov 2012) ISSN: 1468-3083 [Electronic] England
• PMID: 23067433 (Publication Type: Case Reports, Journal Article)
• Copyright: © 2012 The Author. Journal of the European Academy of Dermatology and Venereology © 2012 European Academy of Dermatology and Venereology.

Chemical References

• Anti-Inflammatory Agents
• methylprednisolone aceponate
• Methylprednisolone

Topics

• Administration, Topical
• Anti-Inflammatory Agents (administration & dosage, therapeutic use)
• Dermatitis, Atopic (complications, drug therapy)
• Humans
• Infant
• Male
• Methylprednisolone (administration & dosage, analogs & derivatives, therapeutic use)
• Sleep Wake Disorders (etiology)