[Peculiarities of cerebrovascular effects of GABA conjugate with docosahexaenoyl dopamine under conditions of separate and combined vascular pathology of brain and heart].

Abstract

A GABA conjugate with docosahexaenoyl dophamine (DHED) enhanced local cerebral blood flow in rats under conditions of global transient cerebral ischemia, experimental myocardial infarction, and combined vascular pathology of brain and heart. At the same time, the GABA-DHED conjugate did not influence brain hemoperfusion in intact animals. The cerebrovascular effect of this conjugate is determined by its direct action on the vascular tone, since no changes in blood pressure have been observed. Under conditions of the combined vascular pathology of brain and heart, the cerebrovascular effect of GABA-DHED conjugate is inhibited by bicuculline, which is evidence for the involvement of GABAergic mechanisms in the drug action upon cerebrovascular tone.

• Authors: R S Mirzoian, T S Gan'shina, N A Khaĭlov, I N Kurdiumov, M A Lebedeva, N M Gretskaia, V V Bezuglov
• Journal: Eksperimental'naia i klinicheskaia farmakologiia (Eksp Klin Farmakol) Vol. 75 Issue 7 Pg. 15-9 ( 2012) ISSN: 0869-2092 [Print] Russia (Federation)
• PMID: 23025047 (Publication Type: English Abstract, Journal Article)

Chemical References

• GABA Agents
• GABA-A Receptor Antagonists
• N-docosahexaenoyl dopamine
• gamma-Aminobutyric Acid
• Dopamine
• Bicuculline

Topics

• Animals
• Bicuculline (antagonists & inhibitors, pharmacology)
• Brain (blood supply, pathology, physiopathology)
• Cerebrovascular Circulation (drug effects)
• Coronary Circulation (drug effects)
• Coronary Vessels (pathology, physiopathology)
• Dopamine (analogs & derivatives, pharmacology)
• Drug Antagonism
• GABA Agents
• GABA-A Receptor Antagonists (pharmacology)
• Heart (physiopathology)
• Male
• Rats
• gamma-Aminobutyric Acid (analogs & derivatives, pharmacology)