Distribution of fluconazole-resistant Candida bloodstream isolates among hospitals and inpatient services in Israel.
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| Abstract |
The emergence of fluconazole-resistant Candida (FRC) is worrisome, but little is known about susceptibility patterns in different nosocomial settings. We prospectively analysed Candida bloodstream isolates in 18 medical centres in Israel (six tertiary-care and 12 community hospitals). The study included 444 episodes of candidaemia (450 patient-specific isolates, 8.5% fluconazole-resistant). Institutional FRC bloodstream infection rates correlated with annual inpatient days, and were strongly associated with the presence and activity of haematology/oncology services. Infection with Candida krusei and fluconazole-resistant Candida glabrata occurred exclusively in hospitals with >600 beds. These findings suggest that empirical antifungal strategies should be tailored to the nosocomial setting.
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| Authors | R Ben-Ami, G Rahav, H Elinav, I Kassis, I Shalit, T Gottesman, O Megged, M Weinberger, P Ciobotaro, P Shitrit, G Weber, A Paz, D Miron, I Oren, J Bishara, C Block, N Keller, D P Kontoyiannis, M Giladi, Israeli Candidaemia Study Group |
| Journal | Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases (Clin Microbiol Infect) Vol. 19 Issue 8 Pg. 752-6 (Aug 2013) ISSN: 1469-0691 [Electronic] England |
| PMID | 23005038 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't) |
| Copyright | © 2012 The Authors. Clinical Microbiology and Infection © 2012 European Society of Clinical Microbiology and Infectious Diseases. |
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