Abstract | BACKGROUND/AIMS: METHODS:
NAFLD (n = 96) and controls (n = 139) were enrolled in this study. GERD symptoms were evaluated by using a frequency scale for the symptoms of GERD. RESULTS:
GERD symptom score and its prevalence rate were higher in the NAFLD group (7.4 ± 0.7, 37%) than those seen in the control groups (4.5 ± 0.4, 20%), which was independent of sex, age, and body mass index (BMI). GERD symptoms were correlated with insulin resistance (r = 0.167, p = 0.011), total cholesterol (T-CHO) (r = 0.138, p = 0.034), triglyceride (TG) (r = 0.178, p = 0.006), or immunoreactive insulin (r = 0.173, p = 0.008) but not BMI (r = 0.089, p = 0.175). GERD symptoms of the NAFLD group were significantly severer in the higher group of T-CHO and TG levels than those in the lower group. Multivariate analysis proved that risk factors related to GERD symptoms were TG (OR 3.96, 95% CI 1.31-11.9) and T-CHO (OR 3.39, 95% CI 1.11-10.3). CONCLUSION: The severity and prevalence of GERD symptoms in patients with NAFLD were high, which was associated with serum levels of TG and T-CHO but not BMI.
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Authors | Yoshiko Fujikawa, Kazunari Tominaga, Hideki Fujii, Hirohisa Machida, Hirotoshi Okazaki, Hirokazu Yamagami, Tetsuya Tanigawa, Kenji Watanabe, Toshio Watanabe, Yasuhiro Fujiwara, Toshifumi Matsuura, Norifumi Kawada, Tetsuo Arakawa |
Journal | Digestion
(Digestion)
Vol. 86
Issue 3
Pg. 228-37
( 2012)
ISSN: 1421-9867 [Electronic] Switzerland |
PMID | 22964626
(Publication Type: Comparative Study, Journal Article)
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Copyright | Copyright © 2012 S. Karger AG, Basel. |
Chemical References |
- Biomarkers
- Triglycerides
- Cholesterol
|
Topics |
- Adult
- Aged
- Biomarkers
(blood)
- Cholesterol
(blood)
- Cross-Sectional Studies
- Fatty Liver
(blood, complications, epidemiology)
- Female
- Gastroesophageal Reflux
(blood, epidemiology, etiology)
- Humans
- Japan
(epidemiology)
- Male
- Middle Aged
- Non-alcoholic Fatty Liver Disease
- Obesity, Abdominal
(blood, complications)
- Prevalence
- Retrospective Studies
- Risk Factors
- Triglycerides
(blood)
|