The antimicrobial and osteoinductive properties of silver nanoparticle/poly (DL-lactic-co-glycolic acid)-coated stainless steel.

Abstract	Implant-associated bacterial infections are one of the most serious complications in orthopedic surgery. Treatment of these infections often requires multiple operations, device removal, long-term systemic antibiotics, and extended rehabilitation, and is frequently ineffective, leading to worse clinical outcomes and increased financial costs. In this study, we evaluated silver nanoparticle/poly(DL-lactic-co-glycolic acid) (PLGA)-coated stainless steel alloy(SNPSA) as a potential antimicrobial implant material. We found that SNPSA exhibited strong antibacterial activity in vitro and ex vivo, and promoted MC3T3-E1 pre-osteoblasts proliferation and maturation in vitro. Furthermore, SNPSA implants induced osteogenesis while suppressing bacterial survival in contaminated rat femoral canals. Our results indicate that SNPSA has simultaneous antimicrobial and osteoinductive properties that make it a promising therapeutic material in orthopedic surgery.
Authors	Yi Liu, Zhong Zheng, Janette N Zara, Chingyun Hsu, Donnalisa E Soofer, Kevin S Lee, Ronald K Siu, Lloyd S Miller, Xinli Zhang, Doug Carpenter, Chunling Wang, Kang Ting, Chia Soo
Journal	Biomaterials (Biomaterials) Vol. 33 Issue 34 Pg. 8745-56 (Dec 2012) ISSN: 1878-5905 [Electronic] Netherlands
PMID	22959466 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.)
Copyright	Published by Elsevier Ltd.
Chemical References	Anti-Bacterial Agents Coated Materials, Biocompatible Stainless Steel Polylactic Acid-Polyglycolic Acid Copolymer Polyglycolic Acid Lactic Acid Silver
Topics	3T3 Cells Animals Anti-Bacterial Agents (chemistry, pharmacology) Bacteria (drug effects) Bacterial Infections (drug therapy, etiology) Coated Materials, Biocompatible (chemistry, pharmacology) Femur (diagnostic imaging, growth & development, microbiology) Lactic Acid (chemistry) Male Mice Nanoparticles (chemistry) Osteoblasts (cytology) Osteogenesis Polyglycolic Acid (chemistry) Polylactic Acid-Polyglycolic Acid Copolymer Prostheses and Implants (adverse effects) Radiography Rats Rats, Sprague-Dawley Silver (chemistry, pharmacology) Stainless Steel (chemistry)

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