Decline of the hemoglobin adduct of 4-aminobiphenyl during withdrawal from smoking.

Abstract

The hemoglobin adduct of the human bladder carcinogen 4-aminobiphenyl (4ABP-Hb) declined in the blood of 34 smokers enrolled in a withdrawal program, from a mean of 120 +/- 7 (SE) pg/g of hemoglobin at the start to a mean of 82 +/- 6 pg/g after 3 weeks and a mean of 34 +/- 5 pg/g among the 15 exsmokers who had not resumed smoking after 2 months. Although 4ABP-Hb declined faster than expected under the assumption that the human erythrocyte has a life span of 120 days, it persisted much longer than cotinine. Therefore, 4ABP-Hb may complement the use of cotinine as a marker of exposure to tobacco smoke. The strength of the within-person association of 4ABP-Hb with smoking, coupled with the weakness of the between-person association (correlation coefficient, 0.33), is evidence that between-person variation in modifying factors is substantial. Study of the modifiers of 4ABP-Hb levels may help elucidate the etiology of human susceptibility to aromatic amine-induced bladder cancer.

• Authors: M Maclure, M S Bryant, P L Skipper, S R Tannenbaum
• Journal: Cancer research (Cancer Res) Vol. 50 Issue 1 Pg. 181-4 (Jan 01 1990) ISSN: 0008-5472 [Print] United States
• PMID: 2293553 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Biomarkers
• Hemoglobins
• hemoglobin, 4-aminobiphenyl-
• Cotinine

Topics

• Adult
• Aged
• Biomarkers (blood)
• Cotinine (blood)
• Female
• Hemoglobins (analysis)
• Humans
• Male
• Middle Aged
• Smoking (blood)
• Time Factors