Cytokine profiles of patients with enterohemorrhagic Escherichia coli O111-induced hemolytic-uremic syndrome.

Abstract

Proinflammatory cytokines are related to the pathogenesis of enterohemorrhagic Escherichia coli (EHEC) infection and hemolytic-uremic syndrome (HUS). We assessed the kinetics of the release of cytokines such as neopterin, interleukin (IL)-6, IL-8 and tumour necrosis factor (TNF)-α and the soluble forms of type I and II TNF receptors during EHEC O111-induced HUS (EHEC O111/HUS). Fourteen patients with EHEC O111/HUS were enrolled in this study. Serum concentrations of all cytokines other than TNF-α were significantly elevated in patients with severe HUS compared with those in patients with mild HUS. Although serum concentrations of TNF-α were not significantly higher in patients with severe HUS, most patients with acute encephalopathy showed elevated TNF-α levels. Serum concentrations of these cytokines rapidly and markedly increased, and massive hypercytokinaemia developed 1 day before the diagnosis of HUS in patients with severe HUS. Changes in the number of white blood cells and concentration of serum lactate dehydrogenase were significantly larger between the onset of hemorrhagic colitis and the time of the diagnosis of HUS in patients with severe HUS compared with those in patients with mild HUS. Proinflammatory cytokines play an important role in the pathogenesis of EHEC infection and development of severe complications, including HUS and encephalopathy. Monitoring the cytokine profile may be useful for assessing disease activity of EHEC O111 infections.

• Authors: Masaki Shimizu, Mondo Kuroda, Natsumi Sakashita, Michio Konishi, Hisashi Kaneda, Noboru Igarashi, Junya Yamahana, Hiromichi Taneichi, Hirokazu Kanegane, Mika Ito, Shigeru Saito, Kazuhide Ohta, Takumi Taniguchi, Kengo Furuichi, Takashi Wada, Masaru Nakagawa, Hitoshi Yokoyama, Akihiro Yachie
• Journal: Cytokine (Cytokine) Vol. 60 Issue 3 Pg. 694-700 (Dec 2012) ISSN: 1096-0023 [Electronic] England
• PMID: 22929411 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2012 Elsevier Ltd. All rights reserved.

Chemical References

• Cytokines
• Interleukin-6
• Interleukin-8
• Receptors, Tumor Necrosis Factor
• Tumor Necrosis Factor-alpha
• Neopterin
• L-Lactate Dehydrogenase

Topics

• Adolescent
• Adult
• Child
• Cytokines (blood)
• Enterohemorrhagic Escherichia coli
• Escherichia coli Infections (complications, microbiology)
• Female
• Hemolytic-Uremic Syndrome (blood, etiology, microbiology)
• Humans
• Infant
• Interleukin-6 (blood)
• Interleukin-8 (blood)
• L-Lactate Dehydrogenase (blood)
• Leukocyte Count
• Male
• Neopterin (blood)
• Receptors, Tumor Necrosis Factor (blood)
• Tumor Necrosis Factor-alpha (blood)
• Young Adult