[Progress in new vaccine strategies against influenza: a review].

Abstract

Influenza, caused by influenza virus, is a serious respiratory illness which poses a global public health threat. Vaccination is the primary strategy for the prevention and control of influenza. Although both inactivated vaccines and the live attenuated vaccines are effective in preventing influenza, the current vaccines have poor efficacy in the elderly and fail to provide protection against heterosubtype viruses. Development of a safer and more effective influenza vaccine that provides broad cross protection, overcoming the intrinsic limitation of the current vaccines, has been a scientific challenge. During the past decades, structural biology, reverse genetic and other virological technologies developed quickly and sped the progress of influenza vaccinology. Some new strategies for developing influenza vaccine have been generated, produced encouraging results, which showed great prospect as next-generation of influenza vaccines.

• Authors: Zhihui Liu, Tao Jiang, Ede Qin, Duoliang Ran, Chengfeng Qin
• Journal: Sheng wu gong cheng xue bao = Chinese journal of biotechnology (Sheng Wu Gong Cheng Xue Bao) Vol. 28 Issue 5 Pg. 550-6 (May 2012) ISSN: 1000-3061 [Print] China
• PMID: 22916493 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't, Review)

Chemical References

• Hemagglutinin Glycoproteins, Influenza Virus
• Influenza Vaccines
• Vaccines, Attenuated
• Vaccines, Inactivated

Topics

• Disease Outbreaks (prevention & control)
• Hemagglutinin Glycoproteins, Influenza Virus (immunology)
• Humans
• Influenza Vaccines (biosynthesis, immunology)
• Influenza, Human (immunology, prevention & control, virology)
• Orthomyxoviridae (immunology)
• Vaccines, Attenuated (immunology)
• Vaccines, Inactivated (immunology)