Abstract |
Herpes simplex viruses 1 and 2 (HSV-1 and HSV-2) are responsible for lifelong latent infections in humans, with periods of viral reactivation associated with recurring ulcerations in the orofacial and genital tracts. In immunosuppressed patients and neonates, HSV infections are associated with severe morbidity and, in some cases, even mortality. Today, acyclovir is the standard therapy for the management of HSV infections. However, the need for novel antiviral agents is apparent, since HSV isolates resistant to acyclovir therapy are frequently isolated in immunosuppressed patients. In this study, we assessed the anti-HSV activity of the antiadenoviral compounds 2-[2-(2-benzoylamino)-benzoylamino] benzoic acid (benzavir-1) and 2-[4,5-difluoro-2-(2-fluorobenzoylamino)-benzoylamino] benzoic acid (benzavir-2) on HSV-1 and HSV-2. Both compounds were active against both viruses. Importantly, benzavir-2 had potency similar to that of acyclovir against both HSV types, and it was active against clinical acyclovir-resistant HSV isolates.
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Authors | Mårten Strand, Koushikul Islam, Karin Edlund, Christopher T Oberg, Annika Allard, Tomas Bergström, Ya-Fang Mei, Mikael Elofsson, Göran Wadell |
Journal | Antimicrobial agents and chemotherapy
(Antimicrob Agents Chemother)
Vol. 56
Issue 11
Pg. 5735-43
(Nov 2012)
ISSN: 1098-6596 [Electronic] United States |
PMID | 22908173
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- 2-(4,5-difluoro-2-(2-fluorobenzoylamino)benzoylamino)benzoic acid
- Antiviral Agents
- Benzamides
- Acyclovir
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Topics |
- Acyclovir
(pharmacology, therapeutic use)
- Adult
- Aged, 80 and over
- Animals
- Antiviral Agents
(pharmacology, therapeutic use)
- Benzamides
(pharmacology, therapeutic use)
- Cell Line
- Chlorocebus aethiops
- Drug Resistance, Viral
(drug effects)
- Female
- Herpes Simplex
(drug therapy, virology)
- Herpesvirus 1, Human
(drug effects, growth & development, isolation & purification)
- Herpesvirus 2, Human
(drug effects, growth & development, isolation & purification)
- Humans
- Male
- Middle Aged
- Viral Load
(drug effects)
- Viral Plaque Assay
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