Tumor oxygen measurements and personalized medicine.

Abstract

Tumor hypoxia is probably the most important not yet measurable factor that predicts the outcome of cancer therapy. Hypoxic tumors are resistant to radiation, chemotherapy, and surgery. They signal tumor cells to grow, invade, survive cytotoxic-factor assault, and increase metastatic activity. Therapies aimed at reversing hypoxia-related treatment resistance or normalizing hypoxia are proven effective with level 1 evidence. The weak link remains the lack of satisfactory methods of measurement of tumor oxygenation.

• Authors: Paul Okunieff, Walter O'Dell, Mei Zhang, Lurong Zhang, David Maguire
• Journal: Advances in experimental medicine and biology (Adv Exp Med Biol) Vol. 765 Pg. 195-201 ( 2013) ISSN: 0065-2598 [Print] United States
• PMID: 22879033 (Publication Type: Journal Article, Review)

Chemical References

• Oxygen

Topics

• Humans
• Hypoxia (drug therapy)
• Neoplasms (blood supply, metabolism, therapy)
• Oxygen (analysis)
• Precision Medicine