Drug-induced TINU syndrome and genetic characterization.

Abstract

Tubulointerstitial nephritis and uveitis (TINU) syndrome is due to a disregulation of cell-mediated immunity and genetical predisposition due a particular molecular characterization. We report the case of a 50-year-old woman who was admitted for acute renal failure. She had recently taken flurbiprofen for 10 d for recurrent bronchitis. A renal biopsy revealed acute tubulointerstitial nephritis. Prednisone was started and prognosis was favorable. Three months later the patient developed transitory blurred vision. The diagnosis was bilateral uveitis and she received topic and systemic corticosteroid therapy, with resolution of ocular symptoms. Recurrent episodes of uveitis experienced during the next 12 months were treated with same therapy. Genomic haplotype in our patients was HLA A*0278/2631,-B*1517/3802,- Cw*0701/1202, -DRB1*0101/1359 (DRB3* 52), -DQA1*0102/0102, DQB1*0603/0603. TINU syndrome is characterized by tubulointerstitial nephritis that tends to be selflimiting, whereas uveitis tends to relapse. HLA-DQA1*01 and -DQB1*06 haplotypes are strongly associated with TINU syndrome. This is the first report of TINU syndrome induced by flubiprofen intake. Our case emphasizes the importance of the association between drug exposure and strong susceptibility to TINU syndrome giving the molecular characterization.

• Authors: Domenico Santoro, Giuseppe Vita, Stefania Rovito, Lucia Venuto, Vittorio Cavallari, Roberto Vita, Vincenzo Savica, Guido Bellinghieri, Sebastiano Gangemi
• Journal: Clinical nephrology (Clin Nephrol) Vol. 78 Issue 3 Pg. 230-6 (Sep 2012) ISSN: 0301-0430 [Print] Germany
• PMID: 22874112 (Publication Type: Case Reports, Journal Article)

Chemical References

• Anti-Inflammatory Agents
• Anti-Inflammatory Agents, Non-Steroidal
• HLA-D Antigens
• Histocompatibility Antigens Class I
• Flurbiprofen
• Prednisone

Topics

• Anti-Inflammatory Agents (therapeutic use)
• Anti-Inflammatory Agents, Non-Steroidal (adverse effects)
• Female
• Flurbiprofen (adverse effects)
• HLA-D Antigens (genetics)
• Haplotypes
• Histocompatibility Antigens Class I (genetics)
• Humans
• Middle Aged
• Nephritis, Interstitial (chemically induced, drug therapy, genetics)
• Prednisone (therapeutic use)
• Uveitis (chemically induced, drug therapy, genetics)