Tubulointerstitial nephritis and uveitis

A rare disorder characterized by ANTERIOR UVEITIS, tubulointerstital nephritis or GLOMERULONEPHRITIS, circulating ANTIGEN-ANTIBODY COMPLEXES, and non-caseating GRANULOMAS in the bone marrow and lymph nodes. An association with certain HLA alleles has been observed, especially HLA-DRB1*0102. OMIM: 607665

Also Known As:

Dobrin syndrome; TINU syndrome; Tubulointerstitial Nephritis with Uveitis; Tubulointerstitial nephritis and uveitis syndrome

Networked: 96 relevant articles (5 outcomes, 5 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Uveitis
2.	Interstitial Nephritis (Tubulointerstitial Nephritis)
3.	Nephritis
4.	IGA Glomerulonephritis (IGA Nephropathy)
5.	Inflammation (Inflammations)

Experts

1.	Su, Tao: 4 articles (11/2020 - 01/2011)
2.	Liu, Gang: 3 articles (11/2020 - 01/2011)
3.	Yang, Li: 3 articles (11/2020 - 01/2014)
4.	Yang, Liu: 3 articles (11/2020 - 01/2011)
5.	Lava, Sebastiano A G: 2 articles (01/2022 - 07/2011)
6.	Simonetti, Giacomo D: 2 articles (01/2022 - 07/2011)
7.	Fila, Marc: 2 articles (12/2021 - 01/2021)
8.	Kitamura, Hiroshi: 2 articles (09/2021 - 06/2009)
9.	Jahnukainen, Timo: 2 articles (01/2021 - 01/2019)
10.	Praga, Manuel: 2 articles (01/2021 - 09/2015)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Tubulointerstitial nephritis and uveitis:

1.	Adrenal Cortex Hormones (Corticosteroids)IBA 02/28/2015 - "We made a diagnosis of TINU syndrome because we could not explain the origin, and treated her with a systemic corticosteroid. " 01/01/2006 - "The diagnosis of TINU syndrome was established and the patient was treated with oral corticosteroids. " 01/01/2018 - "TINU syndrome was characterized by limited responsiveness to corticosteroid therapy and less by severe complications. " 06/01/2016 - "This work also suggests that oral corticosteroids are effective for the treatment of TINU syndrome's uveitis. " 07/01/2004 - "In spite of these posterior lesions, clinical course confirmed the previously reported favorable visual outcome of TINU syndrome treated with corticosteroids. "
2.	SteroidsIBA 01/01/2012 - "We suggest low-dose steroid maintenance therapy to decrease the recurrence of the TINU syndrome." 10/01/2011 - "Steroid therapy may be effective to treat TINU syndrome irrespective of the onset of the disease." 04/01/2007 - "Although tubular abnormalities involving TINU syndrome has already been reported, the disease associated with full type Fanconi syndrome has rarely been seen, and systemic steroid may be beneficial in reducing the development of tubulointerstitial injury." 11/01/2012 - "A rare case of acute renal failure due to tubulointerstitial nephritis and uveitis syndrome successfully treated with steroid." 01/01/1993 - "It is suggested that tubulointerstitial nephritis and uveitis (TINU) is a cell-mediated immune disease with a favourable response to treatment with steroids. "
3.	Prednisolone (Predate)FDA LinkGeneric 06/01/2009 - "The objective of this study was to evaluate, retrospectively, serial renal biopsy findings in three girls with TINU syndrome who were treated with prednisolone. " 07/01/2009 - "We suggest short course of cyclophosphamide and prednisolone for treatment of TINU syndrome to decrease the recurrence of kidney and ocular involvement." 10/01/2005 - "The ocular inflammation generally responded well to treatment with oral corticosteroids, and the number of recurrences was lower at corticosteroid doses of > or = prednisolone 40 mg. Ophthalmologists play an important role in the initial discovery of patients with TINU syndrome. "
4.	Cyclosporine (Ciclosporin)FDA LinkGeneric 05/01/2004 - "An 11-year-old boy with recurrent nephritis due to tubulointerstitial nephritis associated with uveitis (TINU syndrome) was treated with cyclosporin A (CSA) to induce sustained remission. "
5.	Immunoglobulin G (IgG)IBA 01/01/2022 - "Analysis showed high levels of La/SS-B, anti-SARS-CoV-2 IgG with confirmed the suspicion of post-covid TINU syndrome. " 04/01/2012 - "TINU (tubulointerstitial nephritis and uveitis) syndrome is not usually associated with IgG4 sclerosing disease." 06/01/2001 - "We suggest that IgG antibody may contribute to tubular dysfunction in some patients with TINU syndrome." 01/01/2011 - "Frozen normal human kidney and iris were used to demonstrate co-localization of human IgG and mCRP from patients with TINU syndrome with laser scanning confocal microscopy. " 06/01/2001 - "On the other hand, TINU syndrome is characterized by hypergammaglobulinemia and high serum immunoglobulin G (IgG) levels, suggesting an involvement of humoral immunity. "
6.	HLA-DQA1 antigen (HLA DQA1)IBA 02/01/2003 - "Based on the results of the present study and on previously reported HLA associations in patients with TINU syndrome, the alphabeta dimer encoded by HLA-DQA101/DQB105 may be particularly important in conferring risk for development of this disease." 09/01/2012 - "HLA-DQA101 and -DQB106 haplotypes are strongly associated with TINU syndrome. " 01/01/2018 - "HLA-DQA1, -DQB1, and -DRB1 have been associated with development of tubulointerstitial nephritis and uveitis (TINU) syndrome in case reports and small case series, but information about HLA genetic susceptibility to drug hypersensitivity-related ATIN (D-ATIN) or other types of ATIN is limited. " 11/01/2015 - "Human leukocyte antigen (HLA) typing (HLA-DQA10101/0201 and HLA-DQB10303/0503) was found which supported the suspect of TINU syndrome. " 02/01/2003 - "TINU syndrome is strongly associated with HLA-DQA101, HLA-DQB105, and HLA-DRB1*01. "
7.	AutoantibodiesIBA 01/01/2011 - "The mCRP autoantibodies were detected in all nine patients with TINU syndrome, significantly higher than that of those with disease controls (P < 0.05). " 06/01/2001 - "Tubulointerstitial nephritis and uveitis syndrome with autoantibody directed to renal tubular cells." 04/01/2008 - "Presence of autoantibodies against tubular and uveal cells in a patient with tubulointerstitial nephritis and uveitis (TINU) syndrome." 01/01/2011 - "The study presented here investigates the possible role of IgG autoantibodies against mCRP in patients with TINU syndrome. " 01/01/2011 - "mCRP autoantibodies were screened by ELISA with purified human C-reactive protein in 9 patients with TINU syndrome, 11 with drug-associated acute interstitial nephritis, 20 with IgA nephropathy, 19 with minimal change disease, 20 with ANCA-associated vasculitis, 6 with Sjogren's syndrome, and 12 with amyloidosis. "
8.	HLA-DQB1 antigen (HLA DQB1)IBA 02/01/2023 - " study adds to the previous knowledge that HLA-DQB105 could be an important HLA type amongst the TINU Syndrome Iberian population. " 11/01/2015 - "Human leukocyte antigen (HLA) typing (HLA-DQA10101/0201 and HLA-DQB10303/0503) was found which supported the suspect of TINU syndrome. " 02/01/2003 - "TINU syndrome is strongly associated with HLA-DQA101, HLA-DQB105, and HLA-DRB101. "
9.	CreatinineIBA 02/01/2015 - "Our analysis revealed that the positive predictive value of increased β2M combined with increased serum creatinine was 100% for detecting definitive and/or probable TINU syndrome. " 02/01/2015 - "These data suggest that urinary β2M and serum creatinine levels are sensitive and relatively simple diagnostic screening tools for detecting renal dysfunction to diagnose TINU syndrome in young patients with uveitis similar to those evaluated in this study." 02/01/2015 - "The value of measuring urinary β2-microglobulin and serum creatinine for detecting tubulointerstitial nephritis and uveitis syndrome in young patients with uveitis." 02/01/2015 - "A post hoc analysis was performed to determine whether urinary β2M, urinary protein, serum creatinine, estimated glomerular filtration rate, and/or pyuria were correlated with definitive and probable cases of TINU syndrome. " 02/01/2015 - "To determine whether urinary β2-microglobulin (β2M), urinary protein, and serum creatinine have predictive value for detecting TINU syndrome in young patients with uveitis. "
10.	TinIBA 01/01/2021 - "The most frequent causes were tubulointerstitial nephritis and uveitis syndrome in 31% and drug-induced TIN in 30% (the majority of these caused by non-steroidal anti-inflammatory drugs). " 01/01/2021 - "Inclusion criteria were TIN and a clinical history of either sarcoidosis or TINU syndrome. " 02/28/2015 - "Although TINU syndrome is characterized by idiopathic TIN with bilateral anterior uveitis, few reports have provided a comprehensive summary of the features of this disorder. " 08/25/2022 - "Tubulointerstitial nephritis and uveitis syndrome (TINU) is a rare disorder typically characterized by sudden-onset non-granulomatous anterior uveitis associated with tubulointerstitial nephritis (TIN). " 01/01/2021 - "TIN is also a hallmark of tubulointerstitial nephritis and uveitis (TINU) syndrome. "

Therapies and Procedures

1.	Therapeutics 03/01/2013 - "Tubulointerstitial nephritis and uveitis syndrome has a potential to develop CNV that leads to severe visual loss; therefore, prompt anti-inflammatory therapy is required, and IVB should be regarded as a potential choice of treatment." 08/01/1999 - "Thyroid function should be evaluated in patients with tubulointerstitial nephritis and uveitis syndrome and symptomatic therapy provided when necessary." 01/01/2022 - "Both of the patients with tuberculosis, and the patient with TINU syndrome developed ESKD months after the kidney biopsy, despite appropriate therapies. " 10/01/2012 - "TINU syndrome can occur in the elderly and should be part of the differential diagnosis when seeing a patient who has uveitis in association with renal disease; any therapy should be managed by both an internist and an ophthalmologist." 10/01/2010 - "To describe the clinical manifestations and response to therapy of adult patients with tubulointerstitial nephritis and uveitis (TINU) syndrome and to provide suggested work-up and treatment. "
2.	Slit Lamp 09/01/2009 - "Slit-lamp examination revealed bilateral anterior non-granulomatous uveitis and TINU syndrome was diagnosed. "
3.	Immunomodulation 10/01/2021 - "Immunomodulation and TNF-α inhibition for tubulointerstitial nephritis and uveitis syndrome: a case series."
4.	Renal Replacement Therapy (Therapies, Renal Replacement) 12/20/2021 - "As the patient in this case showed symptoms of uremia on admission, we decided to establish renal replacement therapy, which is unusual in tubulointerstitial nephritis and uveitis syndrome. " 12/20/2021 - "Renal replacement therapy-requiring acute kidney injury due to tubulointerstitial nephritis and uveitis syndrome: case report."
5.	Kidney Transplantation 09/01/2011 - "We report for the time a patient with recurrence of tubulointerstitial nephritis and uveitis (TINU) following renal transplantation. "