Hyper-eosinophilia in granular acute B-cell lymphoblastic leukemia with myeloid antigen expression.

Abstract

Acute lymphoblastic leukemia with eosinophilia (ALLEo) is a rare but a distinctive clinical entity. Clinical features of idiopathic hyper-eosinophilic syndrome (HES) can be seen in patients with ALLEo. We report a 10-year-old girl, in whom HES was initially suspected but further investigation confirmed the diagnosis of acute B-cell lymphoblastic leukemia with myeloid antigen expression. Clinical response to chemotherapy was excellent with achievement of complete remission for 4 years. Serum interleukin-3 and -5 were elevated at presentation and normalized with disappearance of eosinophilia after induction therapy, supporting the reactive nature of eosinophilia in ALLEo. Hematologic malignancy should be considered in patients with hyper-eosinophilia, before attributing it to HES.

• Authors: Daisuke Kobayashi, Kazuhiro Kogawa, Kohsuke Imai, Toshio Tanaka, Akiko Sada, Shigeaki Nonoyama
• Journal: Pediatrics international : official journal of the Japan Pediatric Society (Pediatr Int) Vol. 54 Issue 4 Pg. 543-6 (Aug 2012) ISSN: 1442-200X [Electronic] Australia
• PMID: 22830543 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2012 The Authors. Pediatrics International © 2012 Japan Pediatric Society.

Chemical References

• Sialic Acid Binding Ig-like Lectin 3

Topics

• Child
• Eosinophilia (complications, immunology)
• Female
• Humans
• Leukemia, B-Cell (complications, immunology)
• Precursor Cell Lymphoblastic Leukemia-Lymphoma (complications, immunology)
• Sialic Acid Binding Ig-like Lectin 3 (biosynthesis)