Abstract | BACKGROUND: METHODS AND RESULTS: The impact of age, duration of illness, sex, race, ventricular geometry, and diagnosis of myocarditis on outcome in 261 children with dilated cardiomyopathy enrolled in the Pediatric Cardiomyopathy Registry and Pediatric Heart Transplant Study was studied. End points included listing as United Network for Organ Sharing status 1, death while waiting, and death after transplantation. The median age at the time of diagnosis was 3.4 years, and the mean time from diagnosis to listing was 0.62±1.3 years. Risk factors associated with death while waiting were ventilator use and older age at listing in patients not mechanically ventilated (P=0.0006 and P=0.03, respectively). Shorter duration of illness (P=0.04) was associated with listing as United Network for Organ Sharing status 1. Death after transplantation was associated with myocarditis at presentation (P=0.009), nonwhite race (P<0.0001), and a lower left ventricular end-diastolic dimension z score at presentation (P=0.04). In the myocarditis group, 17% (4 of 23) died of acute rejection after transplantation. CONCLUSIONS:
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Authors | Biagio A Pietra, Paul F Kantor, Heather L Bartlett, Clifford Chin, Charles E Canter, Ranae L Larsen, R Erik Edens, Steven D Colan, Jeffrey A Towbin, Steven E Lipshultz, James K Kirklin, David C Naftel, Daphne T Hsu |
Journal | Circulation
(Circulation)
Vol. 126
Issue 9
Pg. 1079-86
(Aug 28 2012)
ISSN: 1524-4539 [Electronic] United States |
PMID | 22800850
(Publication Type: Journal Article, Multicenter Study, Research Support, N.I.H., Extramural)
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Topics |
- Age Factors
- Cardiomyopathy, Dilated
(complications, mortality, surgery)
- Cause of Death
- Child
- Child, Preschool
- Female
- Heart Transplantation
- Heart Ventricles
(diagnostic imaging)
- Humans
- Infant
- Kaplan-Meier Estimate
- Male
- Myocarditis
(complications)
- Postoperative Complications
(mortality)
- Proportional Hazards Models
- Racial Groups
- Respiration, Artificial
- Risk Factors
- Severity of Illness Index
- Ultrasonography
- Ventricular Dysfunction, Left
(etiology)
- Waiting Lists
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