Abstract | PURPOSE: The aim of this study was to evaluate by serial measurements, pupil mydriasis produced by topical application of tropicamide 1% using a spray in a closed eye or instillation in an open eye in adult and elderly populations. METHODS: The research was done from February to April of 2011 in the Policlinica Ronaldo Gazolla, located in the Arcos da Lapa Campus of Estacio de Sá University, RJ- Brazil. It was a clinical trial, controlled and randomized, made in a series of 50 patients that were being prepared for ophthalmoscopy examination. They were submitted to eye drop administration of 1% tropicamide in an open eye and to eyelid margin vaporization in a closed eye. The eyes were chosen for the administration of drops or spray according to a pseudo-random numbers table from Excel (2007) before application. The pupil diameter was measured before instillation and after 10, 20, and 30 min in both eyes, with a millimeter ruler. Biostat 5.0 software was used for statistical calculations. RESULTS:
Tropicamide 1% was vaporized in a group that presented the following average pupil diameters: 3 mm before the application; 4.16 mm in 10 min; 5 mm in 20 min; and 5.35 mm in 30 min. The group in which tropicamide 1% was instilled presented 2.96 mm of average pupil diameter before the application; 4.22 mm at 10 min; 5.02 mm at 20 min; and 5.44 at 30 min. The two way analysis of variance showed P<0.0001, and the Tukey test performed for comparisons among the groups showed statistical significant differences among all groups except when the measurements were done at the same time. CONCLUSION:
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Authors | Arlindo José Freire Portes, Annamaria Ciminelli Barbosa, Guilherme Laport de Mello, Marcelo Antunes Lopes, Rachel Simões Cavalcanti |
Journal | Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics
(J Ocul Pharmacol Ther)
Vol. 28
Issue 6
Pg. 632-5
(Dec 2012)
ISSN: 1557-7732 [Electronic] United States |
PMID | 22775152
(Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Mydriatics
- Ophthalmic Solutions
- Tropicamide
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Topics |
- Administration, Ophthalmic
- Administration, Topical
- Aged
- Analysis of Variance
- Brazil
- Female
- Humans
- Male
- Middle Aged
- Mydriatics
(administration & dosage, pharmacology)
- Nebulizers and Vaporizers
- Ophthalmic Solutions
- Ophthalmoscopy
- Pupil
(drug effects)
- Time Factors
- Tropicamide
(administration & dosage, pharmacology)
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