p-Cymene protects mice against lipopolysaccharide-induced acute lung injury by inhibiting inflammatory cell activation.

Abstract

The objective of this study was to test the hypothesis that p-cymene can attenuate acute lung injury induced by lipopolysaccharide (LPS) in vivo. In the mouse model of LPS-induced acute lung injury, intraperitoneal preconditioning with p-cymene resulted in a significant reduction of pro-inflammatory cytokines (TNF-α, IL-1β and IL-6), lung water gain, inflammatory cell infiltration, lung tissue myeloperoxidase activity. In addition, p-cymene blocked the phosphorylation of IκBα protein and mitogen-activated protein kinases (MAPK) signaling pathway activation. Histopathologic examination of lung tissue indicated that p-cymene treatment markedly decreased focal thickening, congestion, pulmonary edema, and inflammatory cells infiltration. The results showed that p-cymene had a protective effect on LPS-induced ALI in mice.

• Authors: Guanghong Xie, Na Chen, Lanan Wassy Soromou, Fang Liu, Ying Xiong, Qianchao Wu, Hongyu Li, Haihua Feng, Guowen Liu
• Journal: Molecules (Basel, Switzerland) (Molecules) Vol. 17 Issue 7 Pg. 8159-73 (Jul 06 2012) ISSN: 1420-3049 [Electronic] Switzerland
• PMID: 22772811 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Cymenes
• Cytokines
• Inflammation Mediators
• Lipopolysaccharides
• Monoterpenes
• NF-kappa B
• Protective Agents
• Water
• 4-cymene
• Peroxidase
• Mitogen-Activated Protein Kinases

Topics

• Acute Lung Injury (enzymology, pathology, prevention & control)
• Animals
• Bronchoalveolar Lavage Fluid (cytology)
• Cell Count
• Cymenes
• Cytokines (metabolism)
• Inflammation (pathology)
• Inflammation Mediators (metabolism)
• Lipopolysaccharides
• Lung (drug effects, enzymology, pathology)
• MAP Kinase Signaling System (drug effects)
• Mice
• Mitogen-Activated Protein Kinases (metabolism)
• Monoterpenes (chemistry, pharmacology)
• NF-kappa B (metabolism)
• Peroxidase (metabolism)
• Protective Agents (chemistry, pharmacology)
• Water