Efficacy of systematic pelvic lymphadenectomy in patients with non-endometrioid endometrial cancers: a retrospective, multicenter study in Korea.

Abstract

AIM:

Non-endometrioid endometrial cancer is a clinically and pathologically distinct subtype of endometrial cancer. The aim of this study was to determine whether systematic pelvic lymphadenectomy improves overall survival compared to no lymphadenectomy in non-endometrioid endometrial cancer.

MATERIAL AND METHODS:

The authors retrospectively reviewed the medical records and pathological findings of 112 patients who underwent surgical staging for non-endometrioid endometrial cancer from 2000 to 2006 in Korea.

RESULTS:

Systematic pelvic lymphadenectomy was performed in 71 patients. Pelvic lymph node metastases were identified in 31% and 14.6% patients who underwent systematic pelvic lymphadenectomy and no lymphadenectomy, respectively. After adjusting for risk factors, there was no significant difference in overall survival (odds ratio = 0.69; 95% confidence interval, 0.29-1.67) between patients who did or did not undergo systematic pelvic lymphadenectomy. On multivariate analysis, patients with lymph node metastasis had higher risk of death (odds ratio = 3.11; 95% confidence interval, 0.97-10.00) than the patients with no lymph node metastasis.

CONCLUSION:

Although systematic pelvic lymphadenectomy did not affect overall survival in patients with the non-endometrioid subtype, it has the potential benefit of providing prognostic information and acting as a guide for further adjuvant treatment.

• Authors: Seo-Yun Tong, Jong-Min Lee, Young-Joon Choi, Jae-Kwan Lee, Mi-Kyung Kim, Chi-Heum Cho, Seok-Mo Kim, Sang-Yoon Park, Chan-Yong Park, Ki-Tae Kim
• Journal: The journal of obstetrics and gynaecology research (J Obstet Gynaecol Res) Vol. 38 Issue 11 Pg. 1321-7 (Nov 2012) ISSN: 1447-0756 [Electronic] Australia
• PMID: 22612243 (Publication Type: Evaluation Study, Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't)
• Copyright: © 2012 The Authors. Journal of Obstetrics and Gynaecology Research © 2012 Japan Society of Obstetrics and Gynecology.

Topics

• Adult
• Aged
• Aged, 80 and over
• Endometrial Neoplasms (mortality, pathology, surgery)
• Female
• Follow-Up Studies
• Humans
• Hysterectomy
• Lymph Node Excision
• Lymphatic Metastasis
• Middle Aged
• Neoplasm Staging
• Ovariectomy
• Pelvis
• Republic of Korea
• Retrospective Studies
• Salpingectomy
• Survival Analysis
• Treatment Outcome