Cortical thinning in subcortical vascular dementia with negative 11C-PiB PET.

Abstract

To determine the existence of cortical thinning in subcortical vascular dementia (SVaD) with a negative 11C-Pittsburgh compound B (PiB) positron emission tomography scan and to compare the topography of cortical thinning between PiB-negative SVaD and Alzheimer's disease (AD), we enrolled 24 patients with PiB(-) SVaD, 81 clinically probable AD individuals, and 72 normal cognitive controls. Compared with controls, cortical thinning in PiB(-) SVaD was most profound in the perisylvian area, medial prefrontal area, and posterior cingulate gyri, while the precuneus and medial temporal lobes were relatively spared. When the cortical thickness of AD and PiB(-) SVaD were directly compared, PiB(-) SVaD demonstrated significant cortical thinning in the bilateral inferior frontal, superior temporal gyri, and right medial frontal and orbitofrontal lobes, while AD showed significant cortical thinning in the right medial temporal region. SVaD without amyloid burden may lead to substantial cortical atrophy. Moreover, characteristic topography of cortical thinning in PiB(-) SVaD suggests different mechanisms of cortical thinning in PiB(-) SVaD and AD.

• Authors: Chi Hun Kim, Sang Won Seo, Geon Ha Kim, Ji Soo Shin, Hanna Cho, Young Noh, Suk-Hui Kim, Min Ji Kim, Seun Jeon, Uicheul Yoon, Jong-Min Lee, Seung Jun Oh, Jae Seung Kim, Sung Tae Kim, Jae-Hong Lee, Duk L Na
• Journal: Journal of Alzheimer's disease : JAD (J Alzheimers Dis) Vol. 31 Issue 2 Pg. 315-23 ( 2012) ISSN: 1875-8908 [Electronic] Netherlands
• PMID: 22531413 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• 2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole
• Aniline Compounds
• Benzothiazoles
• Carbon Radioisotopes
• Thiazoles

Topics

• Aged
• Aniline Compounds
• Benzothiazoles
• Carbon Radioisotopes
• Cerebral Cortex (diagnostic imaging, pathology)
• Dementia, Vascular (diagnostic imaging, pathology)
• Female
• Humans
• Male
• Middle Aged
• Positron-Emission Tomography (methods)
• Single-Blind Method
• Thiazoles